Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL515828 | 0.93 | PTPN1 (0.36) | PTPN1ALDH1A1THRBP4HBGPR55 | |
| SCHEMBL449518 | 0.86 | SMN1; SMN2 (0.42) | ALDH1A1LMNATHRBCYP3A4CYP1A2 | |
| SCHEMBL449604 | 0.86 | SMN1; SMN2 (0.42) | ALDH1A1LMNATHRBCYP3A4CYP1A2 | |
| SCHEMBL10187562 | 0.70 | MEN1 (0.35) | ALDH1A1LMNATHRBCYP3A4CYP1A2 | |
| SCHEMBL406669 | 0.68 | SLC6A2 (0.41) | ALDH1A1CYP1A2CYP2C19SLC6A2SLC6A4 | |
| SCHEMBL11539847 | 0.66 | MEN1 (0.38) | ALDH1A1LMNACYP1A2CYP2C19KMT2A | |
| SCHEMBL16018035 | 0.65 | CYP3A4 (0.44) | PTPN1ALDH1A1P4HBGPR55CYP3A4 | |
| SCHEMBL449517 | 0.65 | LMNA (0.37) | ALDH1A1LMNASMN1; SMN2GAAKDM4E | |
| SCHEMBL15839585 | 0.65 | SLC6A3 (0.31) | ALDH1A1CHRM1TBXA2RADRA1ASLC6A3 | |
| SCHEMBL447364 | 0.64 | NOS3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869052-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND PAK INHIBITORS | AstraZeneca AB (SE) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106326-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND PAK INHIBITORS | ASTRAZENECA AB (SE) | 2006-10-12 | — | — | WO | claimed |
| EP-2393769-B1 | NOVEL HERBICIDES | SYNGENTA LTD (GB) | 2014-12-10 | — | — | EP | disclosed |
| US-8680339-B2 | Herbicides | SYNGENTA LIMITED (GB) | 2014-03-25 | — | — | US | disclosed |
| US-20120028800-A1 | NOVEL HERBICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2393769-A1 | NOVEL HERBICIDES | Syngenta Limited (GB) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089210-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2010-08-12 | — | — | WO | disclosed |
| EP-2144630-A2 | CHK1 INHIBITORS WITH B CELL DEPLETING ANTIBODIES FOR THE TREATMENT OF HEMATOLOGIC MALIGNANCIES | AstraZeneca AB (SE) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008132500-A2 | CHKL INHIBITORS WITH B CELL DEPLETING ANTIBODIES FOR THE TREATMENT OF HEMATOLOGIC MALIGNANCIES | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028800-A1 | NOVEL HERBICIDES | DDT, CYP4X1, CYP1B1 | PTPN1 374/4885ALDH1A1 14/4885LMNA 4657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.