Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | TPH1 | P17752 | 2/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960935 | 0.86 | SLC7A5 (0.48) | TPH1SLC7A5ALDH1A1MMP8PTGS1 | |
| SCHEMBL5151172 | 0.85 | TPH1 (0.39) | TPH1SLC7A5ALDH1A1LMNAPOLB | |
| SCHEMBL5155245 | 0.84 | HDAC8 (0.45) | HDAC8HDAC6TPH1SLC7A5ALDH1A1 | |
| SCHEMBL27559555 | 0.82 | TPH1 (0.41) | TPH1SLC7A5ALDH1A1LMNAHSD17B10 | |
| SCHEMBL5150706 | 0.81 | HRH3 (0.47) | TPH1SLC7A5ALDH1A1LMNAPOLB | |
| SCHEMBL20543461 | 0.81 | SLC7A5 (0.44) | TPH1SLC7A5ALDH1A1LMNAMMP8 | |
| SCHEMBL9967935 | 0.81 | SLC7A5 (0.44) | TPH1SLC7A5ALDH1A1LMNAMMP8 | |
| SCHEMBL21117856 | 0.81 | SLC7A5 (0.44) | TPH1SLC7A5ALDH1A1LMNAMMP8 | |
| SCHEMBL14139328 | 0.81 | SLC7A5 (0.44) | TPH1SLC7A5ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL5151662 | 0.80 | ALDH1A1 (0.44) | TPH1SLC7A5ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157454-B2 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2007-01-02 | — | — | US | disclosed |
| US-20040116353-A1 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI (FR) | 2004-06-17 | — | — | US | disclosed |