Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40607 | 0.79 | ALDH1A1 (0.60) | ALDH1A1HPGDTSHRHSD17B10SIGMAR1 | |
| SCHEMBL456636 | 0.78 | PDK1 (0.41) | ALDH1A1HPGDTSHRHSD17B10KMT2A | |
| SCHEMBL3604296 | 0.76 | ALDH1A1 (0.39) | ALDH1A1HPGDTSHRKMT2AMEN1 | |
| SCHEMBL11152901 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HPGDTSHRKMT2AMEN1 | |
| SCHEMBL6205054 | 0.76 | ALDH1A1 (0.36) | ALDH1A1HPGDTSHRHSD17B10KMT2A | |
| SCHEMBL2094181 | 0.75 | CALM1 (0.46) | HPGDHSD17B10KMT2AMEN1KDM4E | |
| SCHEMBL16950649 | 0.75 | MAPT (0.36) | ALDH1A1HPGDTSHRHSD17B10MAPT | |
| Bicarbonate SCHEMBL27706334 | 0.75 | ALDH1A1 (0.55) | ALDH1A1HPGDTSHRSIGMAR1KMT2A | |
| SCHEMBL27577083 | 0.75 | ALDH1A1 (0.42) | ALDH1A1HPGDKMT2AMEN1KDM4E | |
| SCHEMBL6552466 | 0.74 | POLB (0.48) | ALDH1A1KMT2AMEN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740947-A2 | FLUORESCENT DYES AND COMPLEXES | CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED (GB) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005098437-A2 | FLUORESCENT DYES AND COMPLEXES | CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTD (GB) | 2005-10-20 | — | — | WO | disclosed |
| US-5622970-A | CONTROLLING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1997-04-22 | — | — | US | disclosed |
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |
| US-5192773-A | Isomerase inhibitor | VERTEX PHARMACEUTICALS, INC. (US) | 1993-03-09 | — | — | US | disclosed |