Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 10/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502473 | 0.88 | EPHX1 (0.46) | EPHX2EPHX1HSD11B1TSHRCNR2 | |
| SCHEMBL6508426 | 0.85 | EPHX1 (0.52) | EPHX2EPHX1HSD11B1TSHRCNR2 | |
| SCHEMBL5157056 | 0.79 | HSD11B1 (0.53) | EPHX2HSD11B1CNR2 | |
| SCHEMBL5157962 | 0.79 | EPHX2 (0.46) | EPHX2KDM4EEPHX1HSD11B1TSHR | |
| SCHEMBL5158943 | 0.72 | TSHR (0.57) | EPHX2EPHX1HSD11B1TSHRCNR2 | |
| SCHEMBL6504693 | 0.70 | EPHX1 (0.53) | EPHX2EPHX1HSD11B1TSHR | |
| SCHEMBL6507024 | 0.68 | HSD11B1 (0.44) | EPHX2HSD11B1 | |
| SCHEMBL5160293 | 0.66 | HSD11B1 (0.55) | EPHX2KDM4EEPHX1HSD11B1TSHR | |
| SCHEMBL6502476 | 0.66 | HSD11B1 (0.57) | EPHX2EPHX1HSD11B1CNR2 | |
| SCHEMBL6503334 | 0.65 | ALDH1A1 (0.42) | KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |