Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504405 | 0.88 | HSD11B1 (0.53) | HSD11B1TSHRKMT2AEPHX2ALDH1A1 | |
| SCHEMBL5157601 | 0.85 | HSD11B1 (0.51) | HSD11B1TSHRKMT2AEPHX2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5154837 | 0.83 | HSD11B1 (0.56) | HSD11B1TSHRKMT2AEPHX2ALDH1A1 | |
| SCHEMBL5158943 | 0.78 | TSHR (0.57) | HSD11B1TSHRKMT2AEPHX2ALDH1A1 | |
| SCHEMBL5160289 | 0.77 | HSD11B1 (0.68) | HSD11B1KMT2AEPHX2ALDH1A1EPHX1 | |
| SCHEMBL18878623 | 0.75 | NR1I2 (0.43) | HSD11B1TSHRALDH1A1KDM4E | |
| SCHEMBL5157293 | 0.74 | HSD11B1 (0.56) | HSD11B1TSHRKMT2AEPHX2ALDH1A1 | |
| SCHEMBL12478444 | 0.71 | HTT (0.37) | HSD11B1TSHRALDH1A1 | |
| SCHEMBL12478447 | 0.71 | HTT (0.37) | HSD11B1TSHRALDH1A1 | |
| SCHEMBL19595500 | 0.70 | HTT (0.43) | TSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |