Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504693 | 0.85 | EPHX1 (0.53) | TSHRHSD11B1EPHX1ALDH1A1MAPT | |
| SCHEMBL5157962 | 0.84 | EPHX2 (0.46) | TSHRHSD11B1EPHX1ALDH1A1MAPT | |
| SCHEMBL6502473 | 0.81 | EPHX1 (0.46) | TSHRHSD11B1EPHX1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL5154837 | 0.79 | HSD11B1 (0.56) | TSHRHSD11B1EPHX1ALDH1A1KMT2A | |
| SCHEMBL5160293 | 0.78 | HSD11B1 (0.55) | TSHRHSD11B1EPHX1ALDH1A1KMT2A | |
| SCHEMBL6504405 | 0.76 | HSD11B1 (0.53) | TSHRHSD11B1EPHX1ALDH1A1KMT2A | |
| SCHEMBL5157601 | 0.74 | HSD11B1 (0.51) | TSHRHSD11B1EPHX1ALDH1A1KMT2A | |
| SCHEMBL9108708 | 0.72 | GRM2 (0.53) | HSD11B1CNR1CNR2 | |
| SCHEMBL9108702 | 0.72 | GRM2 (0.53) | HSD11B1CNR1CNR2 | |
| SCHEMBL5157050 | 0.72 | EPHX2 (0.44) | TSHRHSD11B1EPHX1EPHX2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CHENG HENGMIAO | 2005-11-24 | — | — | US | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CYP11B1, HSD11B1, CYP11B2 | TSHR 2376/4885HSD11B1 2/4885EPHX1 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.