SCHEMBL5157381

SCHEMBL5157381

Clc1ccc2nc3cc(Cl)ccc3nc2c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 2/20 0.58
ALDH1A1 P00352 2/20 0.55
MAPT P10636 2/20 0.55
KDM4E B2RXH2 1/20 0.55
MEN1 O00255 1/20 0.55
USP2 O75604 1/20 0.55
KMT2A Q03164 1/20 0.55
HSD17B10 Q99714 1/20 0.55
F7 P08709 1/20 0.54
F3 P13726 1/20 0.54
DYRK1A Q13627 1/20 0.54
PIK3R1 P27986 1/20 0.53
PIK3CA P42336 1/20 0.53
NR4A2 P43354 1/20 0.48
LMNA P02545 1/20 0.45
CYP1A2 P05177 1/20 0.45
THRB P10828 1/20 0.45
ALOX15 P16050 1/20 0.45
MAPK1 P28482 1/20 0.45
POLB P06746 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5157721 0.92 NQO2 (0.56) PIK3CGALDH1A1MAPTKDM4EMEN1
SCHEMBL29856205 0.92 NQO2 (0.56) PIK3CGALDH1A1MAPTKDM4EMEN1
SCHEMBL29581162 0.89 TDP1 (0.55) PIK3CGALDH1A1MAPTKDM4EMEN1
SCHEMBL404069 0.89 TDP1 (0.55) PIK3CGALDH1A1MAPTKDM4EMEN1
SCHEMBL17269519 0.89 PIK3CG (0.54) PIK3CGALDH1A1MAPTKDM4EMEN1
SCHEMBL15196672 0.89 PIK3CG (0.54) PIK3CGALDH1A1MAPTKDM4EMEN1
SCHEMBL11596282 0.88 NQO2 (0.65) PIK3CGALDH1A1MAPTKDM4EMEN1
SCHEMBL2368025 0.88 HSD17B10 (0.52) PIK3CGALDH1A1MAPTKDM4EMEN1
SCHEMBL14166725 0.88 MAPT (0.60) PIK3CGALDH1A1MAPTKDM4EMEN1
SCHEMBL29581721 0.85 HSD17B10 (0.53) PIK3CGALDH1A1MAPTKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1457813-B1 An improved electrochromic medium capable of producing a pre-selected color GENTEX CORP (US) 2007-01-24 EP disclosed
EP-1457813-A2 An improved electrochromic medium capable of producing a pre-selected color Gentex Corporation (US) 2004-09-15 EP disclosed
EP-0972227-B1 AN IMPROVED ELECTROCHROMIC MEDIUM CAPABLE OF PRODUCING A PRE-SELECTED COLOR GENTEX CORP (US) 2004-07-14 EP disclosed
US-6037471-A FOR ELECTROCHROMIC MIRRORS FOR MOTOR VEHICLES GENTEX CORPORATION (US) 2000-03-14 US disclosed
US-6020987-A Electrochromic medium capable of producing a pre-selected color GENTEX CORPORATION (US) 2000-02-01 US disclosed
EP-0972227-A1 AN IMPROVED ELECTROCHROMIC MEDIUM CAPABLE OF PRODUCING A PRE-SELECTED COLOR GENTEX CORPORATION (US) 2000-01-19 EP disclosed
US-5998617-A MIXTURE OF ELECTROACTIVE MATERIALS AT PRESELECTIVE CONCENTRATION; GRAY COLOR GENTEX CORPORATION (US) 1999-12-07 US disclosed
WO-1998044384-A1 AN IMPROVED ELECTROCHROMIC MEDIUM CAPABLE OF PRODUCING A PRE-SELECTED COLOR GENTEX CORPORATION (US) 1998-10-08 WO disclosed