SCHEMBL29856205

SCHEMBL29856205

Clc1ccc2nc3ccccc3nc2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 5/20 0.56
MAPT P10636 5/20 0.55
PIK3R1 P27986 1/20 0.53
PIK3CA P42336 1/20 0.53
TDP1 Q9NUW8 1/20 0.52
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52
USP2 O75604 2/20 0.52
NPC1 O15118 2/20 0.52
POLB P06746 2/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
CACNA1B Q00975 1/20 0.52
APBA1 Q02410 1/20 0.52
PIK3CG P48736 1/20 0.52
KDM4E B2RXH2 4/20 0.50
ALDH1A1 P00352 3/20 0.50
HSD17B10 Q99714 1/20 0.50
HCRTR1 O43613 1/20 0.49
CASP1 P29466 1/20 0.49
CASP7 P55210 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5157721 1.00 NQO2 (0.56) NQO2MAPTPIK3R1PIK3CATDP1
SCHEMBL5157381 0.92 PIK3CG (0.58) NQO2MAPTPIK3R1PIK3CATDP1
SCHEMBL11596282 0.91 NQO2 (0.65) NQO2MAPTPIK3R1PIK3CATDP1
SCHEMBL17269519 0.82 PIK3CG (0.54) MAPTPIK3R1PIK3CAMEN1KMT2A
SCHEMBL29581162 0.82 TDP1 (0.55) MAPTPIK3R1PIK3CATDP1MEN1
SCHEMBL404069 0.82 TDP1 (0.55) MAPTPIK3R1PIK3CATDP1MEN1
SCHEMBL15196672 0.82 PIK3CG (0.54) MAPTPIK3R1PIK3CAMEN1KMT2A
SCHEMBL13770441 0.82 CHEK1 (0.47) NQO2MAPTPIK3R1PIK3CAMEN1
SCHEMBL2368025 0.81 HSD17B10 (0.52) NQO2MAPTPIK3R1PIK3CATDP1
SCHEMBL14166725 0.81 MAPT (0.60) MAPTPIK3R1PIK3CATDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12060334-B2 3-substituted phenazine derivatives as antimicrobial agents UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-08-13 US disclosed
US-20220289689-A1 3-SUBSTITUTED PHENAZINE DERIVATIVES AS ANTIMICROBIAL AGENTS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2022-09-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220289689-A1 3-SUBSTITUTED PHENAZINE DERIVATIVES AS ANTIMICROBIAL AGENTS ROS1, NOX4, NOX5 NQO2 139/4885MAPT 3143/4885PIK3R1 697/4885
US-12060334-B2 3-substituted phenazine derivatives as antimicrobial agents ROS1, NOX4, NOX5 NQO2 139/4885MAPT 3143/4885PIK3R1 697/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.