Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5158011 | 0.82 | HSD11B1 (0.51) | HSD11B1ALDH1A1HSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL5157490 | 0.79 | EPHX2 (0.53) | HSD11B1USP2SMN1; SMN2EPHX2 | |
| SCHEMBL24716617 | 0.79 | SMN1; SMN2 (0.45) | ALDH1A1HSD17B10L3MBTL1USP2SMN1; SMN2 | |
| SCHEMBL24716881 | 0.79 | SMN1; SMN2 (0.45) | ALDH1A1HSD17B10L3MBTL1USP2SMN1; SMN2 | |
| SCHEMBL15746865 | 0.79 | SMN1; SMN2 (0.45) | ALDH1A1HSD17B10L3MBTL1USP2SMN1; SMN2 | |
| SCHEMBL6504975 | 0.77 | CYP1A2 (0.51) | HSD11B1HSD17B10L3MBTL1CYP2C9EPHX2 | |
| SCHEMBL17314784 | 0.77 | SMN1; SMN2 (0.43) | ALDH1A1HSD17B10L3MBTL1USP2SMN1; SMN2 | |
| SCHEMBL17314782 | 0.77 | SMN1; SMN2 (0.43) | ALDH1A1HSD17B10L3MBTL1USP2SMN1; SMN2 | |
| SCHEMBL2737895 | 0.76 | SMN1; SMN2 (0.47) | HSD17B10USP2SMN1; SMN2RECQL | |
| SCHEMBL15561495 | 0.76 | SMN1; SMN2 (0.47) | HSD17B10USP2SMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CHENG HENGMIAO | 2005-11-24 | — | — | US | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CYP11B1, HSD11B1, CYP11B2 | HSD11B1 2/4885ALDH1A1 114/4885HSD17B10 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.