Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5155216 | 0.89 | MAOA (0.48) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL5157543 | 0.85 | KDM4E (0.47) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL3240840 | 0.85 | APP (0.53) | KMT2AMEN1KDM4EMAPTALDH1A1 | |
| SCHEMBL30554590 | 0.85 | APP (0.53) | KMT2AMEN1KDM4EMAPTALDH1A1 | |
| SCHEMBL5157388 | 0.84 | KDM4E (0.48) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL5158018 | 0.83 | MAOA (0.43) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL3245702 | 0.83 | APP (0.48) | KMT2AMEN1KDM4EMAPTALDH1A1 | |
| SCHEMBL30554541 | 0.83 | APP (0.48) | KMT2AMEN1KDM4EMAPTALDH1A1 | |
| SCHEMBL5159722 | 0.83 | MAOA (0.43) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL5158044 | 0.81 | TUBB4A (0.59) | KMT2AMEN1NPC1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1746087-A1 | Derivates of 3-indolylmethylene having cytostatic properties | Universitaet Regensburg (DE) | 2007-01-24 | — | — | EP | disclosed |