Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157388 | 0.87 | KDM4E (0.48) | KDM4EALDH1A1HPGDNPC1MAPT | |
| SCHEMBL5158018 | 0.86 | MAOA (0.43) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL5158461 | 0.85 | KMT2A (0.50) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL5155216 | 0.84 | MAOA (0.48) | KDM4EALDH1A1HPGDNPC1SMN1; SMN2 | |
| SCHEMBL5158044 | 0.84 | TUBB4A (0.59) | KDM4EALDH1A1HPGDNPC1MAPT | |
| SCHEMBL5158006 | 0.83 | MAOA (0.48) | KDM4EALDH1A1HPGDNPC1MAPT | |
| SCHEMBL5289407 | 0.82 | TUBB4A (0.68) | KDM4EALDH1A1HPGDMAPTNPSR1 | |
| SCHEMBL5154906 | 0.81 | MTNR1A (0.49) | KDM4EALDH1A1HPGDMAPTNPSR1 | |
| SCHEMBL5157286 | 0.81 | TUBB4A (0.64) | KDM4EALDH1A1HPGDMAPTNPSR1 | |
| SCHEMBL5157758 | 0.80 | TUBB4A (0.63) | KDM4EALDH1A1HPGDMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010044-A1 | 3-INDOLYLMETHYLENE DERIVATIVES WITH CYTOSTATIC ACTION | UNIVERSITAET REGENSBURG (DE) | 2007-01-25 | — | — | WO | disclosed |
| EP-1746087-A1 | Derivates of 3-indolylmethylene having cytostatic properties | Universitaet Regensburg (DE) | 2007-01-24 | — | — | EP | disclosed |