Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL404515 | 0.85 | ALDH1A1 (0.48) | ALDH1A1MAPK1HTTPOLBSMN1; SMN2 | |
| SCHEMBL16953178 | 0.85 | ALDH1A1 (0.48) | ALDH1A1MAPK1HTTPOLBMCOLN3 | |
| SCHEMBL15250829 | 0.83 | ALDH1A1 (0.47) | ALDH1A1MAPK1HTTPOLBMCOLN3 | |
| SCHEMBL1662886 | 0.80 | ALDH1A1 (0.65) | ALDH1A1MAPK1HTTPOLBMCOLN3 | |
| SCHEMBL28760471 | 0.79 | AKR1C3 (0.47) | ALDH1A1MAPK1POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL2354315 | 0.78 | TSHR (0.64) | ALDH1A1SMN1; SMN2CYP3A4TSHRMAPT | |
| SCHEMBL11199415 | 0.78 | ALDH1A1 (0.54) | ALDH1A1MAPK1HTTSMN1; SMN2AKR1C3 | |
| SCHEMBL4142866 | 0.77 | ALDH1A1 (0.58) | ALDH1A1MAPK1HTTSMN1; SMN2CYP3A4 | |
| SCHEMBL1897174 | 0.77 | ALDH1A1 (0.57) | ALDH1A1MAPK1HTTPOLBMCOLN3 | |
| SCHEMBL30686627 | 0.77 | ALDH1A1 (0.58) | ALDH1A1MAPK1HTTSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022206-A1 | EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS | The Hong Kong University of Science and Technology (CN) | 2016-05-25 | — | — | EP | claimed |
| WO-2015007222-A1 | EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-01-22 | — | — | WO | claimed |
| EP-2403855-B1 | CARBAZOLE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-05-01 | — | — | EP | claimed |
| WO-2011117668-A9 | CARBAZOLE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-10-11 | — | — | WO | claimed |
| EP-3022206-B1 | EPHA4 INHIBITORS AS NEUROPROTECTIVE AGENTS | UNIV HONG KONG SCIENCE & TECH (HK) | 2023-07-12 | — | — | EP | disclosed |
| US-9629830-B2 | EphA4 inhibitors as neuroprotective agents | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-04-25 | — | — | US | disclosed |
| US-20160152618-A1 | EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-06-02 | — | — | US | disclosed |
| EP-3022206-A1 | EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS | The Hong Kong University of Science and Technology (CN) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015007222-A1 | EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-01-22 | — | — | WO | disclosed |
| EP-2403855-B1 | CARBAZOLE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011117668-A9 | CARBAZOLE LINKED PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-10-11 | — | — | WO | disclosed |
| EP-1233013-B1 | NOVEL PHENYLALANINE DERIVATIVES | AJINOMOTO KK (JP) | 2007-02-28 | — | — | EP | disclosed |
| US-7160874-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2007-01-09 | — | — | US | disclosed |
| US-20050070485-A1 | Antagonistic activity to alpha 4 integrin; treating asthma, rheumatoid arthritis; N-[1-N,N-dimethylaminocarbonylcyclopropane-1-ylcarbonyl]-4-({[5-chloro-2-(methylthio)pyrimidine-4-yl]carbonyl}-amino)-L-phenylalanine | AJINOMOTO CO., INC. (JP) | 2005-03-31 | — | — | US | disclosed |
| US-6855706-B2 | Phenylalanine derivatives | AJINOMOTO CO., INC. (JP) | 2005-02-15 | — | — | US | disclosed |
| EP-1233013-A1 | NOVEL PHENYLALANINE DERIVATIVES | Ajinomoto Co., Inc. (JP) | 2002-08-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152618-A1 | EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS | EPHA4, EPHA1, EPHA7 | ALDH1A1 1375/4885MAPK1 145/4885HTT 575/4885 |
| US-20050070485-A1 | Antagonistic activity to alpha 4 integrin; treating asthma, rheumatoid arthritis; N-[1-N,N-dimethylaminocarbonylcyclopropane-1-ylcarbonyl]-4-({[5-chloro-2-(methylthio)pyrimidine-4-yl]carbonyl}-amino)-L-phenylalanine | ITGB4, ITGA4, ITGAL | ALDH1A1 912/4885MAPK1 1853/4885HTT 4723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.