SCHEMBL5158567

SCHEMBL5158567

NC1=C(Cl)C(=O)C(N)=C(Cl)C1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.47
BCHE P06276 2/20 0.47
ACHE P22303 2/20 0.47
CES1 P23141 2/20 0.47
MEN1 O00255 2/20 0.47
ALDH1A1 P00352 2/20 0.47
MAPT P10636 2/20 0.47
RECQL P46063 2/20 0.47
KMT2A Q03164 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
KDM4E B2RXH2 1/20 0.47
TP53 P04637 1/20 0.47
CYP3A4 P08684 1/20 0.47
HPGD P15428 1/20 0.47
ALOX15 P16050 1/20 0.47
TSHR P16473 1/20 0.47
ALOX12 P18054 1/20 0.47
MAPK1 P28482 1/20 0.47
HIF1A Q16665 1/20 0.47
HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8517501 0.93 CES2 (0.60) CES2BCHEACHECES1MEN1
SCHEMBL6109533 0.85 MAPT (0.57) CES2BCHEACHECES1MEN1
SCHEMBL24660101 0.76 CES2 (0.62) CES2BCHEACHECES1MEN1
SCHEMBL30003014 0.73 NSD2 (0.56) CES1MEN1ALDH1A1MAPTRECQL
SCHEMBL29440919 0.73 IDO1 (0.68) CES2BCHECES1MEN1ALDH1A1
SCHEMBL23271807 0.73 NSD2 (0.56) CES1MEN1ALDH1A1MAPTRECQL
SCHEMBL24660100 0.72 CES2 (0.56) CES2BCHEACHECES1MEN1
SCHEMBL14593320 0.71 CDC25B (0.70) MEN1ALDH1A1MAPTRECQLKMT2A
SCHEMBL23271912 0.69 TDP2 (0.53) CES1MEN1ALDH1A1KMT2ACYP3A4
SCHEMBL23271854 0.69 CSNK2A2 (0.54) MEN1ALDH1A1MAPTRECQLKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109608343-B Synthetic method of 2,5-diamino hydroquinone hydrochloride 浙江工业大学 2021-07-27 CN claimed
CN-109608343-A Synthetic method of 2, 5-diamino hydroquinone hydrochloride 浙江工业大学 2019-04-12 CN claimed
EP-1754514-A1 Agent and method for colouring keratin fibres Wella Aktiengesellschaft (DE) 2007-02-21 EP claimed
US-20070000073-A1 Agent and method for colouring keratin fibres PROCTER & GAMBLE COMPANY, THE 2007-01-04 US claimed
WO-2006094217-A2 AGENT AND METHOD FOR COLOURING KERATIN FIBRES THE PROCTER & GAMBLE COMPANY (US) 2006-09-08 WO claimed
US-7070625-B2 Agent and method for coloring keratin fibers containing 2-benzothiazolinone-hydrazone and quinone derivatives WELLA AG (DE) 2006-07-04 US claimed
EP-1448540-A1 AGENT AND METHOD FOR COLORING KERATIN FIBERS CONTAINING 2-BENZOTHIAZOLINONE-HYDRAZONE AND QUINONE DERIVATIVES Wella Aktiengesellschaft (DE) 2004-08-25 EP claimed
US-20040060124-A1 Agent and method for coloring keratin fibers containing 2-benzothiazolinone-hydrazone and quinone derivatives HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) 2004-04-01 US claimed
WO-2003042199-A1 AGENT AND METHOD FOR COLORING KERATIN FIBERS CONTAINING 2-BENZOTHIAZOLINONE-HYDRAZONE AND QUINONE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 2003-05-22 WO claimed
EP-0246112-B1 PREPARATION OF DIAMINO- AND DIALKYLAMINOBENZENEDIOLS THE DOW CHEMICAL COMPANY (US) 1991-06-12 EP claimed
US-4806688-A Preparation of diamino- and dialkylaminobenzenediols THE DOW CHEMICAL COMPANY (US) 1989-02-21 US claimed
WO-1987006930-A1 PREPARATION OF DIAMINO- AND DIALKYLAMINOBENZENEDIOLS THE DOW CHEMICAL COMPANY (US) 1987-11-19 WO claimed
EP-0246112-A1 Preparation of diamino- and dialkylaminobenzenediols THE DOW CHEMICAL COMPANY (US) 1987-11-19 EP claimed
CN-119613720-A Polyimide slurry for flexible display substrate, preparation method of polyimide slurry and preparation method of polyimide film 苏州聚萃材料科技有限公司 2025-03-14 CN disclosed
CN-118956420-A Sodium lauroyl methyl taurate/ammonium bromide salt system and construction and application thereof 北京工商大学 2024-11-15 CN disclosed
CN-115197081-B Low-cost zinc battery positive electrode material and preparation method thereof 扬州大学 2023-11-24 CN disclosed
EP-0060258-A4 METHOD FOR PRODUCING 3,6-BIS(CARBOETHOXYAMINO)-2,5-DIAZIRIDINYL-1,4-BENZOQUINONE. AEROJET GENERAL CO (US) 1982-12-02 EP disclosed
EP-0060258-A1 METHOD FOR PRODUCING 3,6-BIS(CARBOETHOXYAMINO)-2,5-DIAZIRIDINYL-1,4-BENZOQUINONE. AEROJET GENERAL CO (US) 1982-09-22 EP disclosed
US-4337196-A FROM A DIAMINOHYDROQUINONE UNITED STATES OF AMERICA (US) 1982-06-29 US disclosed
WO-1982000823-A1 METHOD FOR PRODUCING 3,6-BIS(CARBOETHOXYAMINO)-2,5-DIAZIRIDINYL-1,4-BENZOQUINONE AEROJET GENERAL CO (US) 1982-03-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040060124-A1 Agent and method for coloring keratin fibers containing 2-benzothiazolinone-hydrazone and quinone derivatives KRT18, NDUFA1, NDUFA2 CES2 3325/4885BCHE 2552/4885ACHE 1891/4885
US-20070000073-A1 Agent and method for colouring keratin fibres KRT18, CDC73, OAT CES2 4013/4885BCHE 1954/4885ACHE 1192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.