Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11306615 | 0.87 | CTSS (0.45) | SYKCTSSCTSKKDM4AKDM4E | |
| SCHEMBL5742834 | 0.80 | CTSK (0.50) | SYKCTSSCTSKMEN1GAA | |
| SCHEMBL4367633 | 0.80 | SERPINE1 (0.39) | SERPINE1TDP1SYKCTSSCTSK | |
| SCHEMBL7825061 | 0.79 | SYK (0.43) | SERPINE1TDP1SYKCTSSCTSK | |
| SCHEMBL7837084 | 0.79 | SYK (0.43) | SERPINE1TDP1SYKCTSSCTSK | |
| SCHEMBL1241387 | 0.78 | AAK1 (0.46) | SERPINE1TDP1SYKCTSSCTSK | |
| SCHEMBL25834163 | 0.77 | S1PR3 (0.42) | SERPINE1SYKMEN1KMT2ASLC6A3 | |
| SCHEMBL5662770 | 0.77 | TSHR (0.41) | CTSSCTSKMEN1KMT2AAAK1 | |
| SCHEMBL257247 | 0.77 | RXFP1 (0.47) | CTSSCTSKMEN1GAAKMT2A | |
| SCHEMBL5693123 | 0.77 | MCHR1 (0.42) | SERPINE1MEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |