Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 3/20 | 0.54 |
| ▸ | STS | P08842 | 5/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.38 |
| ▸ | ESR1 | P03372 | 7/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | PGR | P06401 | 3/20 | 0.37 |
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.37 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SNCA | P37840 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10439848 | 0.80 | SHBG (0.65) | SHBGSTSHSD17B1ESR1LMNA | |
| SCHEMBL8409463 | 0.79 | SHBG (0.45) | SHBGSTSHSD17B1ESR1LMNA | |
| SCHEMBL7163758 | 0.78 | SHBG (0.66) | SHBGSTSHSD17B1ESR1LMNA | |
| SCHEMBL8409776 | 0.76 | STS (0.40) | SHBGSTSHSD17B1ESR1LMNA | |
| SCHEMBL31185604 | 0.76 | STS (0.65) | SHBGSTSHSD17B1ESR1LMNA | |
| SCHEMBL6866101 | 0.74 | STS (0.49) | SHBGSTSHSD17B1ESR1LMNA | |
| SCHEMBL8571107 | 0.72 | SHBG (0.60) | SHBGSTSHSD17B1ESR1LMNA | |
| SCHEMBL3974231 | 0.72 | SHBG (0.57) | SHBGSTSHSD17B1ESR1LMNA | |
| SCHEMBL7864592 | 0.71 | SHBG (1.00) | SHBGSTSHSD17B1ESR1LMNA | |
| SCHEMBL712443 | 0.71 | SHBG (1.00) | SHBGSTSHSD17B1ESR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1405860-B1 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use | STANFORD RES INST INT (US) | 2007-02-14 | — | — | EP | disclosed |
| EP-1405860-A1 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use | SRI INTERNATIONAL (US) | 2004-04-07 | — | — | EP | disclosed |
| US-6046186-A | ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS | SRI INTERNATIONAL (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999033858-A9 | ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | STANFORD RES INST INT (US) | 1999-10-28 | — | — | WO | disclosed |