SCHEMBL8409776

SCHEMBL8409776

CC(=O)Oc1cc2c(c(O[Si](C)(C)C(C)(C)C)c1C=O)[C@H]1CC[C@]3(C)CCC[C@H]3[C@@H]1CC2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STS P08842 3/20 0.40
SHBG P04278 1/20 0.39
ESR1 P03372 4/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
LMNA P02545 2/20 0.35
PGR P06401 1/20 0.35
ADORA3 P0DMS8 1/20 0.35
AR P10275 1/20 0.35
CHRM1 P11229 1/20 0.35
TBXA2R P21731 1/20 0.35
ADRA1A P35348 1/20 0.35
OPRM1 P35372 1/20 0.35
SLC6A3 Q01959 1/20 0.35
ATM Q13315 1/20 0.35
CYP3A4 P08684 2/20 0.33
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
ESR2 Q92731 1/20 0.31
MEN1 O00255 1/20 0.30
ALOX15 P16050 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8409463 0.87 SHBG (0.45) STSSHBGESR1LMNACYP3A4
SCHEMBL5159055 0.76 SHBG (0.54) STSSHBGESR1SMN1; SMN2LMNA
SCHEMBL4669764 0.75 SHBG (0.49) STSSHBGESR1SMN1; SMN2LMNA
SCHEMBL5851260 0.73 SHBG (0.61) STSSHBGESR1SMN1; SMN2LMNA
SCHEMBL8088835 0.71 SHBG (0.54) STSSHBGESR1LMNAMAPT
SCHEMBL4588126 0.70 SHBG (0.56) STSSHBGESR1SMN1; SMN2LMNA
SCHEMBL6866101 0.69 STS (0.49) STSSHBGESR1LMNACYP3A4
SCHEMBL10523211 0.69 SHBG (0.47) STSSHBGESR1SMN1; SMN2LMNA
SCHEMBL31185604 0.68 STS (0.65) STSSHBGESR1SMN1; SMN2LMNA
SCHEMBL8409780 0.66 ESR1 (0.67) STSESR1SMN1; SMN2LMNAPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5861388-A TREATMENT OF ESTROGEN DEPENDENT DISORDERS AS FOR EXAMPLEBREAST CANCER SRI INTERNATIONAL (US) 1999-01-19 US disclosed
WO-1998032763-A1 STEROID INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE SRI INTERNATIONAL (US) 1998-07-30 WO disclosed
US-5763432-A TREATMENT OF ESTROGEN-DEPENDENT DISORDERS SRI INTERNATIONAL (US) 1998-06-09 US disclosed