Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 5/20 | 0.44 |
| ▸ | ESR1 | P03372 | 4/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DAB2IP | Q5VWQ8 | 1/20 | 0.34 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409776 | 0.87 | STS (0.40) | SHBGSTSESR1ESR2HSD17B1 | |
| SCHEMBL8088835 | 0.82 | SHBG (0.54) | SHBGSTSESR1ESR2HSD17B1 | |
| SCHEMBL5159055 | 0.79 | SHBG (0.54) | SHBGSTSESR1ESR2HSD17B1 | |
| SCHEMBL8571107 | 0.73 | SHBG (0.60) | SHBGSTSESR1ESR2HSD17B1 | |
| SCHEMBL31185604 | 0.71 | STS (0.65) | SHBGSTSESR1HSD17B1KDM4E | |
| SCHEMBL3972911 | 0.70 | CYP19A1 (0.69) | SHBGSTSESR1ESR2HSD17B1 | |
| SCHEMBL6866101 | 0.70 | STS (0.49) | SHBGSTSESR1HSD17B1CYP19A1 | |
| SCHEMBL10439848 | 0.69 | SHBG (0.65) | SHBGSTSESR1ESR2HSD17B1 | |
| SCHEMBL17824220 | 0.69 | SHBG (0.53) | SHBGSTSESR1HSD17B1KDM4E | |
| SCHEMBL6869789 | 0.69 | STS (0.64) | SHBGSTSCA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861388-A | TREATMENT OF ESTROGEN DEPENDENT DISORDERS AS FOR EXAMPLEBREAST CANCER | SRI INTERNATIONAL (US) | 1999-01-19 | — | — | US | disclosed |
| WO-1998032763-A1 | STEROID INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SRI INTERNATIONAL (US) | 1998-07-30 | — | — | WO | disclosed |
| US-5763432-A | TREATMENT OF ESTROGEN-DEPENDENT DISORDERS | SRI INTERNATIONAL (US) | 1998-06-09 | — | — | US | disclosed |