Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | NOD1 | Q9Y239 | 10/20 | 0.64 |
| ▸ | TNF | P01375 | 8/20 | 0.64 |
| ▸ | NOD2 | Q9HC29 | 8/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159210 | 0.96 | SMN1; SMN2 (0.72) | SMN1; SMN2KDM4ENOD1TNFNOD2 | |
| SCHEMBL5162557 | 0.85 | MEN1 (0.58) | SMN1; SMN2KDM4ENOD1TNFNOD2 | |
| SCHEMBL4897800 | 0.83 | HDAC1 (0.57) | SMN1; SMN2KDM4ENOD1TNFNOD2 | |
| SCHEMBL16085403 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2KDM4ENOD1TNFNOD2 | |
| SCHEMBL16263700 | 0.80 | SMN1; SMN2 (0.89) | SMN1; SMN2KDM4ENOD1TNFNOD2 | |
| SCHEMBL3698767 | 0.76 | RAB9A (0.79) | SMN1; SMN2KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL7314186 | 0.75 | KDM4E (0.76) | SMN1; SMN2KDM4ENOD1TNFNOD2 | |
| SCHEMBL16085545 | 0.75 | SMN1; SMN2 (0.79) | SMN1; SMN2KDM4ENOD1TNFNOD2 | |
| SCHEMBL16062262 | 0.75 | NOD1 (0.80) | SMN1; SMN2KDM4ENOD1TNFNOD2 | |
| SCHEMBL3478431 | 0.73 | ALDH1A1 (0.59) | KDM4EMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758847-A1 | INHIBITORS OF HISTONE DEACETYLASE | Cancer Research Technology Limited (GB) | 2007-03-07 | — | — | EP | claimed |
| WO-2005121073-A1 | INHIBITORS OF HISTONE DEACETYLASE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-12-22 | — | — | WO | claimed |
| EP-1758847-A1 | INHIBITORS OF HISTONE DEACETYLASE | Cancer Research Technology Limited (GB) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121073-A1 | INHIBITORS OF HISTONE DEACETYLASE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |