Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 13/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 2/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3855873 | 0.90 | KDM4E (0.44) | KMT2AL3MBTL1MEN1LMNATSHR | |
| SCHEMBL3863169 | 0.87 | RAB9A (0.38) | KMT2AMEN1KDM4EBACE1CTSD | |
| SCHEMBL3854478 | 0.84 | LMNA (0.42) | KMT2AL3MBTL1MEN1LMNAKDM4E | |
| SCHEMBL165562 | 0.82 | KDM4E (0.51) | KMT2AL3MBTL1MEN1LMNATSHR | |
| SCHEMBL5156755 | 0.81 | MEN1 (0.39) | KMT2AL3MBTL1MEN1LMNAKDM4E | |
| SCHEMBL3445965 | 0.80 | KDM4E (0.50) | KMT2AL3MBTL1MEN1LMNATSHR | |
| SCHEMBL13229603 | 0.77 | LMNA (0.46) | KMT2AL3MBTL1MEN1LMNATSHR | |
| SCHEMBL475760 | 0.76 | KDM4E (0.56) | KMT2AL3MBTL1MEN1LMNATSHR | |
| SCHEMBL2215353 | 0.76 | L3MBTL1 (0.43) | KMT2AL3MBTL1MEN1LMNATSHR | |
| SCHEMBL4373510 | 0.74 | LMNA (0.36) | KMT2AL3MBTL1MEN1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |