Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | CISD1 | Q9NZ45 | 7/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3860124 | 0.87 | KDM6B (0.41) | KDM6BKDM4CCISD1HSD17B10KDM4E | |
| SCHEMBL5153914 | 0.81 | KDM6B (0.41) | KDM6BKDM4CRIPK1CISD1PLA2G2A | |
| SCHEMBL12723401 | 0.74 | RIPK1 (0.47) | KDM6BKDM4CRIPK1CISD1HSD17B10 | |
| SCHEMBL5159403 | 0.74 | BACE1 (0.42) | KMT2ARIPK1HSD17B10KDM4EHCAR3 | |
| SCHEMBL5176739 | 0.71 | KDM6B (0.41) | KDM6BKDM4CRIPK1CISD1PLA2G2A | |
| SCHEMBL30381149 | 0.71 | ALDH1A1 (0.45) | KMT2AHSD17B10KDM4ESMN1; SMN2GAA | |
| SCHEMBL30381068 | 0.71 | ALDH1A1 (0.45) | KMT2AHSD17B10KDM4ESMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL3855171 | 0.67 | KDM6B (0.43) | KDM6BKDM4CCISD1HSD17B10KDM4E | |
| SCHEMBL12350233 | 0.67 | KMT2A (0.44) | KMT2AHSD17B10KDM4EPDE5AALDH1A1 | |
| SCHEMBL15635588 | 0.66 | KDM4E (0.46) | KDM6BKDM4CRIPK1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |