Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ASPH | Q12797 | 3/20 | 0.37 |
| ▸ | RIOX2 | Q8IUF8 | 3/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12723401 | 0.75 | RIPK1 (0.47) | KDM6BKDM4CRIPK1KDM4EHCAR3 | |
| SCHEMBL5176733 | 0.73 | TLR8 (0.37) | RIPK1KDM4EHCAR3ALDH1A1GAA | |
| SCHEMBL5153914 | 0.72 | KDM6B (0.41) | KDM6BKDM4CRIPK1KDM4EHCAR3 | |
| SCHEMBL5176735 | 0.72 | RIPK1 (0.40) | KDM6BKDM4CRIPK1ASPHKDM8 | |
| SCHEMBL5159406 | 0.71 | KDM6B (0.40) | KDM6BKDM4CRIPK1KDM4EHCAR3 | |
| SCHEMBL9400529 | 0.68 | ASPH (0.70) | KDM6BKDM4CKDM4EASPHRIOX2 | |
| SCHEMBL15635588 | 0.67 | KDM4E (0.46) | KDM6BKDM4CRIPK1KDM4EHCAR3 | |
| SCHEMBL24074333 | 0.66 | RIPK1 (0.42) | KDM6BKDM4CRIPK1KDM4EHCAR3 | |
| SCHEMBL8715959 | 0.66 | CNR2 (0.58) | KDM4EHCAR3ALDH1A1GAAHSD17B10 | |
| SCHEMBL3396257 | 0.66 | KDM4E (0.52) | RIPK1KDM4EHCAR3ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |