Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | CISD1 | Q9NZ45 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159406 | 0.81 | KDM6B (0.40) | KDM6BKDM4CRIPK1CISD1ALDH1A1 | |
| SCHEMBL12723401 | 0.75 | RIPK1 (0.47) | KDM6BKDM4CRIPK1CISD1ALDH1A1 | |
| SCHEMBL5153905 | 0.73 | HCAR3 (0.37) | RIPK1ALDH1A1HCAR3TSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL3855171 | 0.72 | KDM6B (0.43) | KDM6BKDM4CCISD1ALDH1A1HCAR3 | |
| SCHEMBL5153911 | 0.72 | RIPK1 (0.42) | KDM6BKDM4CRIPK1ALDH1A1HCAR3 | |
| SCHEMBL5176739 | 0.72 | KDM6B (0.41) | KDM6BKDM4CRIPK1CISD1ALDH1A1 | |
| SCHEMBL5158867 | 0.68 | KDM4C (0.59) | KDM6BKDM4CCISD1HCAR3KDM4E | |
| SCHEMBL3860124 | 0.67 | KDM6B (0.41) | KDM6BKDM4CCISD1ALDH1A1HCAR3 | |
| SCHEMBL15635588 | 0.67 | KDM4E (0.46) | KDM6BKDM4CRIPK1ALDH1A1HCAR3 | |
| SCHEMBL2880726 | 0.67 | CISD1 (0.78) | CISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |