Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL6243331 | 0.96 | TSHR (0.40) | TSHRGABRA1GABRB2POLBALPL | |
| Ethylenediamine SCHEMBL6472964 | 0.95 | HPGD (0.40) | TSHRGABRA1GABRB2POLBALPL | |
| Ethylenediamine SCHEMBL7181567 | 0.95 | HPGD (0.40) | TSHRGABRA1GABRB2POLBALPL | |
| Ethylenediamine SCHEMBL7182048 | 0.95 | HPGD (0.40) | TSHRGABRA1GABRB2POLBALPL | |
| Ethylenediamine SCHEMBL544736 | 0.81 | TSHR (0.42) | TSHRGABRA1GABRB2POLBHPGD | |
| Ethylenediamine SCHEMBL5159417 | 0.80 | TSHR (0.41) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL10615720 | 0.76 | PTPN9 (0.35) | TSHRGABRA1GABRB2POLBALPL | |
| SCHEMBL1161818 | 0.72 | GABRA1 (0.48) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL5842467 | 0.72 | GABRA1 (0.52) | TSHRGABRA1GABRB2POLBHPGD | |
| Diphenylacetic Acid SCHEMBL28650266 | 0.72 | CTSD (0.47) | POLBALPLALPGTAAR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1752043-B1 | Molluscicide composition, dosage forms comprising such compositions and method for its use. | DENKA REGISTRATIONS B V (NL) | 2015-08-05 | — | — | EP | disclosed |
| EP-1752043-A1 | Molluscicide composition, dosage forms comprising such compositions and method for its use. | Denka International Holding B.V. (NL) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005027617-A2 | FERTILIZER COMPOSITIONS FOR PLANTS CONTAINING PHOSPHATE AND PHOSPHONATE SALTS, METAL CHELATES, AND DERIVATIVES THEREOF | FOLIAR NUTRIENTS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
| EP-1339285-A2 | FUNGICIDAL AND BACTERICIDAL COMPOSITIONS FOR PLANTS CONTAINING PHOSPHONATE AND PHOSPHATE SALTS, METAL CHELATES, AND DERIVATIVES THEREOF | Foliar Nutrients, Inc. (US) | 2003-09-03 | — | — | EP | disclosed |
| US-20020193351-A1 | Fungicidal and bactericidal compositions for plants containing phosphonate and phosphate salts, metal chelates, and derivatives thereof | TAYLOR JOHN B (US) | 2002-12-19 | — | — | US | disclosed |
| WO-2002056680-A2 | FUNGICIDAL AND BACTERICIDAL COMPOSITIONS FOR PLANTS CONTAINING PHOSPHONATE AND PHOSPHATE SALTS, METAL CHELATES, AND DERIVATIVES THEREOF | FOLIAR NUTRIENTS, INC. (US) | 2002-07-25 | — | — | WO | disclosed |
| US-6348193-B1 | Method for inhibiting pathogenic fungi and bacteria in plants using Pseudomonas aureofaciens | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2002-02-19 | — | — | US | disclosed |
| WO-2001015529-A1 | FUNGICIDAL AND BACTERICIDAL COMPOSITIONS FOR PLANTS CONTAINING COMPOUNDS IN THE FORM OF HEAVY METAL CHELATES | FOLIAR NUTRIENTS, INC. (US) | 2001-03-08 | — | — | WO | disclosed |
| US-6139879-A | IN AQUEOUS SOLUTION | FOLIAR NUTRIENTS, INC. (US) | 2000-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193351-A1 | Fungicidal and bactericidal compositions for plants containing phosphonate and phosphate salts, metal chelates, and derivatives thereof | PPM1F, PPA1, PPM1G | TSHR 3412/4885GABRA1 1601/4885GABRB2 1805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.