Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL7181567 | 1.00 | HPGD (0.40) | HPGDKDM4EALDH1A1TSHRGABRA1 | |
| Ethylenediamine SCHEMBL7182048 | 1.00 | HPGD (0.40) | HPGDKDM4EALDH1A1TSHRGABRA1 | |
| Ethylenediamine SCHEMBL6243331 | 0.98 | TSHR (0.40) | HPGDKDM4EALDH1A1TSHRGABRA1 | |
| Ethylenediamine SCHEMBL5159409 | 0.95 | TSHR (0.40) | HPGDKDM4EALDH1A1TSHRGABRA1 | |
| Ethylenediamine SCHEMBL544736 | 0.80 | TSHR (0.42) | HPGDKDM4EALDH1A1TSHRGABRA1 | |
| Ethylenediamine SCHEMBL5159417 | 0.79 | TSHR (0.41) | HPGDKDM4EALDH1A1TSHRGABRA1 | |
| Diphenylacetic Acid SCHEMBL28650266 | 0.74 | CTSD (0.47) | POLBALPLALPGTAAR1TDP1 | |
| SCHEMBL7511207 | 0.72 | HPGD (0.47) | HPGDKDM4EALDH1A1TSHRGABRA1 | |
| SCHEMBL31107078 | 0.72 | HPGD (0.47) | HPGDKDM4EALDH1A1TSHRGABRA1 | |
| SCHEMBL1161818 | 0.71 | GABRA1 (0.48) | HPGDKDM4EALDH1A1TSHRGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005027617-A2 | FERTILIZER COMPOSITIONS FOR PLANTS CONTAINING PHOSPHATE AND PHOSPHONATE SALTS, METAL CHELATES, AND DERIVATIVES THEREOF | FOLIAR NUTRIENTS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
| WO-2001015529-A1 | FUNGICIDAL AND BACTERICIDAL COMPOSITIONS FOR PLANTS CONTAINING COMPOUNDS IN THE FORM OF HEAVY METAL CHELATES | FOLIAR NUTRIENTS, INC. (US) | 2001-03-08 | — | — | WO | disclosed |
| US-6139879-A | IN AQUEOUS SOLUTION | FOLIAR NUTRIENTS, INC. (US) | 2000-10-31 | — | — | US | disclosed |