Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL5159417 | 0.98 | TSHR (0.41) | TSHRGABRA1GABRB2HPGDTAAR1 | |
| SCHEMBL3360155 | 0.90 | GABRA1 (0.50) | TSHRGABRA1GABRB2HPGDAKR1B1 | |
| Ethylene SCHEMBL11785588 | 0.84 | GABRA1 (0.45) | TSHRGABRA1GABRB2HPGDAKR1B1 | |
| Ethylenediamine SCHEMBL5159409 | 0.81 | TSHR (0.40) | TSHRGABRA1GABRB2HPGDTAAR1 | |
| Ethylenediamine SCHEMBL6243331 | 0.81 | TSHR (0.40) | TSHRGABRA1GABRB2HPGDTAAR1 | |
| Ethylenediamine SCHEMBL6472964 | 0.80 | HPGD (0.40) | TSHRGABRA1GABRB2HPGDTAAR1 | |
| Ethylenediamine SCHEMBL7182048 | 0.80 | HPGD (0.40) | TSHRGABRA1GABRB2HPGDTAAR1 | |
| Ethylenediamine SCHEMBL7181567 | 0.80 | HPGD (0.40) | TSHRGABRA1GABRB2HPGDTAAR1 | |
| SCHEMBL11363822 | 0.80 | MEN1 (0.50) | TSHRGABRA1GABRB2HPGDPOLB | |
| SCHEMBL2792375 | 0.79 | GABRA1 (0.45) | TSHRGABRA1GABRB2HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 199 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116553505-A | Iron phosphate-based polyanion positive electrode material, preparation and application | 中国科学院大连化学物理研究所 | 2023-08-08 | — | — | CN | claimed |
| CN-114105274-B | Offshore oilfield sewage water purification and desulfurization auxiliary agent and preparation method thereof | 中海油(天津)油田化工有限公司 | 2023-07-07 | — | — | CN | claimed |
| US-9340707-B2 | Polishing composition to be used to polish semiconductor substrate having silicon through electrode structure, and polishing method using polishing composition | FUJIMI INCORPORATED (JP) | 2016-05-17 | — | — | US | claimed |
| WO-2013144604-A1 | BIOTINIDASE RESISTANT BIOTINYL COMPOUNDS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2013-10-03 | — | — | WO | claimed |
| US-8178742-B2 | Method for in situ reclamation of an area contaminated by organic compounds | ENI S.P.A. (IT) | 2012-05-15 | — | — | US | claimed |
| US-20090299123-A1 | METHOD FOR IN SITU RECLAMATION OF AN AREA CONTAMINATED BY ORGANIC COMPOUNDS | ENI S.P.A. (IT) | 2009-12-03 | — | — | US | claimed |
| EP-2127765-A2 | Method for in situ remediation of an area contaminated by organic compounds | ENI S.p.A. (IT) | 2009-12-02 | — | — | EP | claimed |
| EP-0789071-B1 | METHOD FOR TREATING SURFACE OF SUBSTRATE AND SURFACE TREATMENT COMPOSITION THEREFOR | MITSUBISHI CHEM CORP (JP) | 2006-10-11 | — | — | EP | claimed |
| US-6896744-B2 | Method for cleaning a surface of a substrate | MITSUBISHI CHEMICAL CORPORATION (JP) | 2005-05-24 | — | — | US | claimed |
| US-20040099290-A1 | Method for cleaning a surface of a substrate | MITSUBISHI CHEMICAL CORPORATION (JP) | 2004-05-27 | — | — | US | claimed |
| US-4859575-A | Method for processing of silver halide color photographic material with dialysis treatment | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1989-08-22 | — | — | US | claimed |
| US-4836952-A | COMPRISING A METAL CHELATE RESIN AND AN IRON POWDER; FOOD PRESERVATIVES; CLOTHING; TOOLS; CORROSION RESISTANCE | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1989-06-06 | — | — | US | claimed |
| EP-0283174-A2 | Method for processing lightsensitive silver halide color photographic material improved in color restoration | KONICA CORPORATION (JP) | 1988-09-21 | — | — | EP | claimed |
| EP-0241917-A2 | A deoxygenating composition | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1987-10-21 | — | — | EP | claimed |
| US-4618569-A | USING ION EXCHANGE RESIN AND LIQUID STABILIZER | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1986-10-21 | — | — | US | claimed |
| US-4563405-A | NONSTAINING, STORAGE STABLE | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1986-01-07 | — | — | US | claimed |
| EP-0005346-B1 | ENTEROCHELIN COMPLEXES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND A PROCESS FOR PREPARING THEM | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1983-03-09 | — | — | EP | claimed |
| US-4359477-A | ANTIBACTERIAL AGENTS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1982-11-16 | — | — | US | claimed |
| US-4269850-A | OF INDIUM AND SCANDIUM; ENTERIC INFECTIONS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1981-05-26 | — | — | US | claimed |
| EP-0005346-A1 | Enterochelin complexes, pharmaceutical compositions containing them and a process for preparing them | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1979-11-14 | — | — | EP | claimed |