Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | ESPL1 | Q14674 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5160885 | 0.85 | NPC1 (0.47) | NPC1RAB9AATMMAPTAPAF1 | |
| Hydrochloric Acid SCHEMBL5156733 | 0.81 | NPC1 (0.51) | NPC1RAB9AATMMAPTCYP1A2 | |
| Hydrochloric Acid SCHEMBL5159516 | 0.73 | NPC1 (0.43) | NPC1RAB9AATMMAPTAPAF1 | |
| Hydrochloric Acid SCHEMBL5159524 | 0.72 | NPC1 (0.47) | NPC1RAB9AATMMAPTAPAF1 | |
| Hydrochloric Acid SCHEMBL5158699 | 0.71 | NPC1 (0.62) | NPC1RAB9AATMMAPTESPL1 | |
| Hydrochloric Acid SCHEMBL30343291 | 0.70 | NPC1 (0.65) | NPC1RAB9AATMMAPTAPAF1 | |
| Hydrochloric Acid SCHEMBL599994 | 0.70 | NPC1 (0.65) | NPC1RAB9AATMMAPTAPAF1 | |
| Hydrochloric Acid SCHEMBL7787648 | 0.69 | NPC1 (0.56) | NPC1RAB9AATMMAPTAPAF1 | |
| SCHEMBL11694301 | 0.69 | NPC1 (0.62) | NPC1RAB9AATMESPL1CYP1A2 | |
| Hydrochloric Acid SCHEMBL5159533 | 0.69 | NPC1 (0.46) | NPC1RAB9AATMMAPTAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473330-B1 | Process for the synthesis of oxonol compound | FUJI PHOTO FILM CO LTD (JP) | 2007-02-14 | — | — | EP | disclosed |
| EP-0819977-B1 | Oxonol compound and silver halide photographic material | FUJI PHOTO FILM CO LTD (JP) | 2006-01-04 | — | — | EP | disclosed |
| EP-1473330-A1 | Process for the synthesis of oxonol compound | FUJI PHOTO FILM CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6159673-A | Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound | FUJI PHOTO FILM CO., LTD. (JP) | 2000-12-12 | — | — | US | disclosed |
| EP-0819977-A1 | Oxonol compound, silver halide photographic material and process for the synthesis of oxonol compound | FUJI PHOTO FILM CO., LTD. (JP) | 1998-01-21 | — | — | EP | disclosed |