Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ESPL1 | Q14674 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480244 | 0.78 | SCN2A (0.49) | RAB9AMEN1KMT2AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL5160885 | 0.76 | NPC1 (0.47) | NPC1RAB9AATMMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5158699 | 0.74 | NPC1 (0.62) | NPC1RAB9AATMMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL599994 | 0.73 | NPC1 (0.65) | NPC1RAB9AATMMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30343291 | 0.73 | NPC1 (0.65) | NPC1RAB9AATMMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5159512 | 0.72 | NPC1 (0.44) | NPC1RAB9AATMMEN1KMT2A | |
| SCHEMBL11694301 | 0.72 | NPC1 (0.62) | NPC1RAB9AATMMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5156733 | 0.72 | NPC1 (0.51) | NPC1RAB9AATMMEN1KMT2A | |
| Bromide SCHEMBL5144105 | 0.71 | NPC1 (0.61) | NPC1RAB9AATMMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL31173710 | 0.71 | NPC1 (0.65) | NPC1RAB9AATMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473330-B1 | Process for the synthesis of oxonol compound | FUJI PHOTO FILM CO LTD (JP) | 2007-02-14 | — | — | EP | disclosed |