Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160293 | 0.85 | HSD11B1 (0.55) | HSD11B1EPHX2TSHRCACNA1HEPHX1 | |
| SCHEMBL6504405 | 0.83 | HSD11B1 (0.53) | HSD11B1EPHX2TSHRCACNA1HEPHX1 | |
| Hydrochloric Acid SCHEMBL5154837 | 0.79 | HSD11B1 (0.56) | HSD11B1EPHX2TSHREPHX1KMT2A | |
| SCHEMBL5157591 | 0.79 | HSD11B1 (0.63) | HSD11B1EPHX2ALDH1A1 | |
| SCHEMBL5158943 | 0.74 | TSHR (0.57) | HSD11B1EPHX2TSHREPHX1KMT2A | |
| SCHEMBL5157293 | 0.70 | HSD11B1 (0.56) | HSD11B1EPHX2TSHREPHX1KMT2A | |
| SCHEMBL5157962 | 0.67 | EPHX2 (0.46) | HSD11B1EPHX2TSHREPHX1KMT2A | |
| SCHEMBL12961967 | 0.66 | EPHX2 (0.86) | EPHX2 | |
| SCHEMBL4516091 | 0.65 | EPHX2 (0.67) | EPHX2TSHREPHX1KMT2ALMNA | |
| SCHEMBL9276694 | 0.65 | TSHR (0.62) | HSD11B1EPHX2TSHREPHX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CHENG HENGMIAO | 2005-11-24 | — | — | US | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CYP11B1, HSD11B1, CYP11B2 | HSD11B1 2/4885EPHX2 2185/4885TSHR 2376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.