Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.56 |
| ▸ | FKBP1A | P62942 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157285 | 0.82 | HSD11B1 (0.55) | HSD11B1ALDH1A1EPHX2SMN1; SMN2CYP2D6 | |
| SCHEMBL5160293 | 0.74 | HSD11B1 (0.55) | HSD11B1KMT2AALDH1A1EPHX2EPHX1 | |
| SCHEMBL8546687 | 0.73 | MAPK1 (0.57) | HSD11B1FKBP1AKMT2AALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL5154837 | 0.73 | HSD11B1 (0.56) | HSD11B1FKBP1AKMT2AALDH1A1MEN1 | |
| SCHEMBL6504405 | 0.72 | HSD11B1 (0.53) | HSD11B1KMT2AALDH1A1EPHX2EPHX1 | |
| SCHEMBL5157601 | 0.70 | HSD11B1 (0.51) | HSD11B1KMT2AALDH1A1EPHX2EPHX1 | |
| SCHEMBL8546685 | 0.69 | HSD11B1 (0.54) | HSD11B1FKBP1AKMT2AALDH1A1EPHX2 | |
| SCHEMBL8546679 | 0.69 | HSD11B1 (0.54) | HSD11B1FKBP1AKMT2AALDH1A1EPHX2 | |
| SCHEMBL5158943 | 0.68 | TSHR (0.57) | HSD11B1KMT2AALDH1A1MEN1EPHX2 | |
| SCHEMBL8544832 | 0.67 | HSD11B1 (0.45) | HSD11B1FKBP1AKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745019-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CHENG HENGMIAO | 2005-11-24 | — | — | US | disclosed |
| WO-2005108359-A1 | NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES | PFIZER INC. (US) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CYP11B1, HSD11B1, CYP11B2 | HSD11B1 2/4885FKBP1A 33/4885KMT2A 3470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.