Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.50 |
| ▸ | LDHA | P00338 | 3/20 | 0.46 |
| ▸ | LDHB | P07195 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ATIC | P31939 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160775 | 0.90 | PDE10A (0.49) | PDE10ALDHALDHBTSHRHPGD | |
| SCHEMBL8074031 | 0.86 | LDHA (0.51) | PDE10ALDHALDHBTSHRHPGD | |
| SCHEMBL30706629 | 0.86 | LDHA (0.49) | PDE10ALDHALDHBTSHRHPGD | |
| SCHEMBL19203141 | 0.86 | LDHA (0.49) | PDE10ALDHALDHBTSHRHPGD | |
| SCHEMBL31520079 | 0.86 | LDHA (0.51) | PDE10ALDHALDHBTSHRHPGD | |
| SCHEMBL6171244 | 0.86 | PDE10A (0.49) | PDE10ALDHALDHBTSHRHPGD | |
| SCHEMBL2791364 | 0.85 | KMT2A (0.46) | PDE10ALDHALDHBTSHRHPGD | |
| SCHEMBL2790721 | 0.85 | PDE10A (0.45) | PDE10ALDHALDHBTSHRHPGD | |
| SCHEMBL4415520 | 0.84 | HSD17B10 (0.54) | PDE10ALDHATSHRHPGDHSD17B10 | |
| SCHEMBL31414101 | 0.84 | HSD17B10 (0.54) | PDE10ALDHATSHRHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106176709-B | Pharmaceutical composition for treating tuberculosis and preparation method thereof | 顺天乡大学校产学协力团 | 2020-02-07 | — | — | CN | disclosed |
| EP-2892343-A1 | USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS | Bayer CropScience AG (DE) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014037349-A1 | USE OF SUBSTITUTED 2,3-DIHYDRO-1-BENZOFURAN-4-CARBOXYLIC ACIDS OR SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS | BAYER CROPSCIENCE AG (DE) | 2014-03-13 | — | — | WO | disclosed |
| EP-1000025-B1 | SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1112263-B1 | POLYMERIZABLE POLYALKOXYLATED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-0835870-B1 | Photochromic substituted naphthopyrans | PPG IND OHIO INC (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1112264-B1 | POLYALKOXYLATED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020173667-A1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL LIMITED (IE) | 2002-11-21 | — | — | US | disclosed |
| US-6478989-B1 | Aromatic substituted naphthopyrans | TRANSITIONS OPTICAL, INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1000025-A4 | SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1000025-A1 | SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2000-05-17 | — | — | EP | disclosed |
| US-5961892-A | PHOTOCHROMIC | PPG INDUSTRIES OHIO, INC. (US) | 1999-10-05 | — | — | US | disclosed |
| WO-1998055457-A1 | SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| EP-0835870-A1 | Photochromic substituted naphthopyrans | PPG INDUSTRIES, INC. (US) | 1998-04-15 | — | — | EP | disclosed |
| WO-1998014443-A1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1998-04-09 | — | — | WO | disclosed |
| US-5658500-A | REVERSIBLE PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5656206-A | OPHTHALIMIC LENSES; RADIATION TRANSPARENT; PHOTOCHROMISM | TRANSITIONS OPTICAL, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5650098-A | PHOTOCHROMIC LENSES | TRANSITIONS OPTICAL, INC. (US) | 1997-07-22 | — | — | US | disclosed |
| US-5573712-A | PHOTOCHROMIC ARTICLE COMPRISING ORGANIC HOST AND THE PHOTOCHROMIC NAPHTHOPYRAN | TRANSITIONS OPTICAL, INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5458814-A | Ophthalmic lenses | TRANSITIONS OPTICAL, INC. (US) | 1995-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173667-A1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | TYR, B3GNT2, PAH | PDE10A 4050/4885LDHA 4082/4885LDHB 4381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.