Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23256418 | 0.82 | EPHX1 (0.58) | HPGDLMNAL3MBTL1KMT2APOLB | |
| SCHEMBL14880258 | 0.80 | TAAR1 (0.49) | HPGDL3MBTL1KMT2ATAAR1POLB | |
| SCHEMBL11073553 | 0.80 | LMNA (0.46) | LMNAL3MBTL1KMT2APOLBHTT | |
| SCHEMBL4556503 | 0.79 | POLB (0.50) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL9224777 | 0.79 | SIGMAR1 (0.47) | — | |
| SCHEMBL6094269 | 0.77 | KMT2A (0.55) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL6657928 | 0.77 | POLB (0.47) | LMNAL3MBTL1KMT2APOLBHTT | |
| SCHEMBL19920065 | 0.77 | POLB (0.47) | LMNAL3MBTL1KMT2APOLBHTT | |
| SCHEMBL1063975 | 0.77 | HDAC8 (0.60) | NPC1RAB9A | |
| SCHEMBL1062300 | 0.76 | HDAC8 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126836-B1 | BENZAMIDE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2007-02-14 | — | — | EP | disclosed |
| US-6194458-B1 | 1-(2-METHOXYPHENYL)-1-OXO-2-AZA-(S)-4-I-BUTYL-4-PHENYLBUTANE, FOR EXAMPLE; TREATING VARIOUS CONDITIONS INCLUDING TRANSPLANTATION REJECTION OF ORGANS OR TISSUES IN A PATIENT; IMMUNOSUPPRESSANT COMPOSITIONS | MERCK & CO., INC. | 2001-02-27 | — | — | US | disclosed |