Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162115 | 0.85 | MAPK14 (0.37) | GHSRCA1CA2CA9CA14 | |
| SCHEMBL5160843 | 0.85 | KDM4C (0.35) | GHSRKMT2AMEN1LMNAGRIN2C | |
| SCHEMBL5245974 | 0.85 | HTT (0.39) | ALDH1A1KMT2AMEN1HTTNCOA1 | |
| SCHEMBL5160829 | 0.84 | GHSR (0.38) | HSPB1GHSRALDH1A1MAPTKMT2A | |
| SCHEMBL6223683 | 0.82 | PLA2G7 (0.42) | GHSRNPSR1LMNASMN1; SMN2 | |
| SCHEMBL5713459 | 0.78 | GHSR (0.44) | GHSRKMT2AMEN1L3MBTL1 | |
| SCHEMBL3089273 | 0.77 | ALDH1A1 (0.48) | HSPB1GHSRALDH1A1MAPTKMT2A | |
| SCHEMBL5551729 | 0.77 | ESR1 (0.47) | ALDH1A1KMT2ACA1CA2CA9 | |
| SCHEMBL2121244 | 0.76 | ESR1 (0.40) | — | |
| SCHEMBL6225107 | 0.75 | MAPK1 (0.37) | ALDH1A1KMT2ANPSR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756094-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005123723-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-12-29 | — | — | WO | disclosed |