Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 5/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162115 | 0.89 | MAPK14 (0.37) | KDM4CKDM6BRORCCHRM4ESR1 | |
| SCHEMBL5160824 | 0.85 | HSPB1 (0.40) | MEN1KMT2ALMNAGRIN2CGHSR | |
| SCHEMBL6223683 | 0.85 | PLA2G7 (0.42) | RORCLMNATP53GHSR | |
| SCHEMBL5160848 | 0.83 | KDM4C (0.38) | KDM4CKDM6BRORCCHRM4MEN1 | |
| SCHEMBL5713459 | 0.81 | GHSR (0.44) | CHRM4MEN1KMT2AMTNR1BGHSR | |
| SCHEMBL5551729 | 0.79 | ESR1 (0.47) | KMT2ALMNAESR1ESR2MTNR1B | |
| SCHEMBL2121244 | 0.79 | ESR1 (0.40) | ESR1ESR2 | |
| SCHEMBL6225107 | 0.78 | MAPK1 (0.37) | KDM4CKMT2ALMNATP53 | |
| SCHEMBL6226193 | 0.77 | HRH3 (0.41) | KDM4C | |
| SCHEMBL6225379 | 0.76 | MAPK1 (0.41) | MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756094-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005123723-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-12-29 | — | — | WO | disclosed |