Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA4 | P22748 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16908331 | 0.89 | CA1 (0.55) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL2115137 | 0.86 | MITF (0.57) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL31541868 | 0.84 | SLC6A2 (0.43) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL27784843 | 0.84 | SLC6A2 (0.61) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL27505917 | 0.82 | SLC6A2 (0.63) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL1415727 | 0.82 | SLC6A2 (0.63) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL6936570 | 0.82 | SLC6A2 (0.63) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL9844016 | 0.81 | MITF (0.55) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL25154352 | 0.80 | SLC6A2 (0.47) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL22620855 | 0.80 | SLC6A2 (0.57) | SLC6A4SLC6A3SLC6A2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748984-A1 | PIPERIDINE DERIVATIVES AS NK1 AND NK3 ANTAGONISTS | Pfizer Products Inc. (US) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005110987-A1 | PIPERIDINE DERIVATIVES AS NK1 AND NK3 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-11-24 | — | — | WO | disclosed |