Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2984800 | 0.88 | ALDH1A1 (0.48) | ALDH1A1MAPTGHSRTSHRFFAR2 | |
| SCHEMBL2987025 | 0.86 | SIGMAR1 (0.47) | MCHR1SIGMAR1EPHX2 | |
| SCHEMBL2982852 | 0.84 | TSHR (0.50) | ALDH1A1MAPTTSHR | |
| SCHEMBL2985875 | 0.83 | OPRM1 (0.46) | ALDH1A1TSHREPHX2 | |
| SCHEMBL5158393 | 0.82 | TSHR (0.38) | ALDH1A1GHSRTSHRSIGMAR1 | |
| SCHEMBL2976914 | 0.82 | TSHR (0.49) | ALDH1A1MAPTGHSRTSHREPHX2 | |
| SCHEMBL2985408 | 0.81 | MEN1 (0.47) | ALDH1A1MCHR1SIGMAR1 | |
| SCHEMBL2985406 | 0.81 | TSHR (0.54) | MAPTGHSRTSHR | |
| SCHEMBL2983707 | 0.79 | POLB (0.53) | MCHR1SIGMAR1EPHX2 | |
| SCHEMBL2989322 | 0.78 | MEN1 (0.48) | MAPTTSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007536322-A | — | — | 2007-12-13 | — | — | JP | claimed |
| EP-1747191-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2007-01-31 | — | — | EP | claimed |
| WO-2005110975-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | claimed |