SCHEMBL5161696

SCHEMBL5161696

O=C(O)O[C@@H]1CCCN1C(=O)Nc1ccc(Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.53
CCR1 P32246 9/20 0.51
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
LMNA P02545 1/20 0.49
TP53 P04637 1/20 0.49
MAPT P10636 1/20 0.49
NFKB1 P19838 1/20 0.49
NFKB2 Q00653 1/20 0.49
RELA Q04206 1/20 0.49
THRB P10828 1/20 0.49
ALOX12 P18054 1/20 0.49
KMT2A Q03164 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.48
ALOX5 P09917 1/20 0.47
HSD11B1 P28845 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5164161 0.88 SMN1; SMN2 (0.62) SMN1; SMN2NPC1RAB9ATP53MAPT
SCHEMBL4190364 0.80 THRB (0.75) CCR1THRBALOX12KMT2AL3MBTL1
SCHEMBL20446598 0.80 THRB (0.75) CCR1THRBALOX12KMT2AL3MBTL1
SCHEMBL5734080 0.80 THRB (0.75) CCR1THRBALOX12KMT2AL3MBTL1
SCHEMBL4198615 0.80 NPC1 (0.59) SMN1; SMN2NPC1RAB9ALMNATP53
SCHEMBL4203596 0.78 TAS1R3 (0.41) SMN1; SMN2CCR1NPC1RAB9ALMNA
SCHEMBL5605795 0.78 POLB (0.47) SMN1; SMN2CCR1NPC1RAB9ALMNA
SCHEMBL4216596 0.78 TAS1R3 (0.41) SMN1; SMN2CCR1NPC1RAB9ALMNA
SCHEMBL5162710 0.78 POLB (0.47) SMN1; SMN2CCR1NPC1RAB9ALMNA
SCHEMBL2640102 0.78 TAS1R3 (0.41) SMN1; SMN2CCR1NPC1RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1608646-B1 METHOD FOR THE PRODUCTION OF PYRROLIDINE-1,2-DICARBOXYLIC ACID-1-(PHENYL(-AMIDE))-2-(PHENYL(-AMIDE)) DERIVATIVES AND 1-(PHENYLCARBAMOYL)-PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS INTERMEDIATE PRODUCTS MERCK PATENT GMBH (DE) 2007-07-11 EP disclosed
EP-1760081-A1 Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products Merck Patent GmbH (DE) 2007-03-07 EP disclosed
EP-1608646-A1 METHOD FOR THE PRODUCTION OF PYRROLIDINE-1,2-DICARBOXYLIC ACID-1-(PHENYL(-AMIDE))-2-(PHENYL(-AMIDE)) DERIVATIVES AND 1-(PHENYLCARBAMOYL)-PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS INTERMEDIATE PRODUCTS MERCK PATENT GmbH (DE) 2005-12-28 EP disclosed
WO-2004087695-A1 METHOD FOR THE PRODUCTION OF PYRROLIDINE-1,2-DICARBOXYLIC ACID-1-(PHENYL(-AMIDE))-2-(PHENYL(-AMIDE)) DERIVATIVES AND 1-(PHENYLCARBAMOYL)-PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS INTERMEDIATE PRODUCTS MERCK PATENT GMBH (DE) 2004-10-14 WO disclosed