Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161696 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ACYP2C9CYP2C19 | |
| SCHEMBL31234028 | 0.78 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9APOLBCYP2C9 | |
| SCHEMBL4186674 | 0.78 | KMT2A (0.76) | SMN1; SMN2NPC1RAB9APOLBCYP2C9 | |
| SCHEMBL27627515 | 0.77 | ALDH1A1 (0.79) | SMN1; SMN2NPC1RAB9ACYP2C9CYP2C19 | |
| SCHEMBL5734401 | 0.75 | NPC1 (0.63) | SMN1; SMN2NPC1RAB9APOLBCYP2C9 | |
| SCHEMBL11719448 | 0.75 | KMT2A (0.70) | SMN1; SMN2NPC1RAB9APOLBCYP2C9 | |
| Iodide SCHEMBL10827466 | 0.74 | NPC1 (0.62) | SMN1; SMN2NPC1RAB9APOLBCYP2C9 | |
| SCHEMBL11181068 | 0.74 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9APOLBCYP2C9 | |
| SCHEMBL7309663 | 0.74 | THRB (0.70) | SMN1; SMN2NPC1RAB9APOLBCYP2C9 | |
| SCHEMBL3433977 | 0.74 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9APOLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051975-B1 | SUBSTITUTED PROLINAMIDES, PRODUCTION THEREOF AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM INT (DE) | 2012-09-12 | — | — | EP | disclosed |
| EP-1760081-A1 | Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products | Merck Patent GmbH (DE) | 2007-03-07 | — | — | EP | disclosed |