Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.73 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.73 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.73 |
| ▸ | CDK2 | P24941 | 2/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.60 |
| ▸ | PI4KA | P42356 | 2/20 | 0.60 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.60 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.51 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767031 | 0.84 | CCNE1 (1.00) | CDK1CCNB1CCNE1CDK2ADORA1 | |
| SCHEMBL15354451 | 0.83 | CDK1 (0.73) | CDK1CCNB1CCNE1CDK2ADORA1 | |
| SCHEMBL3440998 | 0.81 | CDK1 (0.71) | CDK1CCNB1CCNE1CDK2ADORA1 | |
| SCHEMBL26349135 | 0.81 | CDK1 (0.71) | CDK1CCNB1CCNE1CDK2ADORA1 | |
| SCHEMBL21451434 | 0.81 | CDK1 (0.71) | CDK1CCNB1CCNE1CDK2ADORA1 | |
| SCHEMBL13233224 | 0.80 | CDK1 (0.69) | CDK1CCNB1CCNE1CDK2ADORA1 | |
| SCHEMBL25306748 | 0.79 | CDK1 (0.50) | CDK1CCNB1CCNE1CDK2ADORA1 | |
| SCHEMBL21755914 | 0.79 | CDK1 (0.67) | CDK1CCNB1CCNE1CDK2ADORA1 | |
| SCHEMBL29388366 | 0.79 | CDK1 (0.67) | CDK1CCNB1CCNE1CDK2ADORA1 | |
| SCHEMBL14131868 | 0.79 | CDK1 (0.64) | CDK1CCNB1CCNE1CDK2ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189730-B2 | A2A adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1456209-B1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2007-02-28 | — | — | EP | disclosed |
| EP-1456209-A1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2004-09-15 | — | — | EP | disclosed |
| US-20030149060-A1 | A2A adenosine receptor antagonists | CV THERAPEUTICS, INC. | 2003-08-07 | — | — | US | disclosed |
| WO-2003051882-A1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149060-A1 | A2A adenosine receptor antagonists | ADORA2A, ADORA2B, ADORA3 | CDK1 1472/4885CCNB1 2940/4885CCNE1 3733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.