Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Papaverine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.58 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.58 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 16/20 | 0.77 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.77 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.77 |
| ▸ | USP2 | O75604 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | PDE4A | P27815 | 2/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.77 |
| ▸ | PDE2A | O00408 | 1/20 | 0.77 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Papaverine SCHEMBL28508832 | 0.91 | PDE10A (0.85) | PDE10APDE3APDE3BLMNACYP3A4 | |
| Papaverine SCHEMBL29886716 | 0.88 | PDE10A (0.69) | PDE10APDE3APDE3BLMNACYP3A4 | |
| Papaverine SCHEMBL9551009 | 0.88 | PDE10A (1.00) | PDE10APDE3APDE3BLMNACYP3A4 | |
| Papaverine SCHEMBL29360983 | 0.88 | PDE10A (1.00) | PDE10APDE3APDE3BLMNACYP3A4 | |
| Papaverine SCHEMBL29387160 | 0.88 | PDE10A (1.00) | PDE10APDE3APDE3BLMNACYP3A4 | |
| Papaverine SCHEMBL34702 | 0.88 | PDE10A (1.00) | PDE10APDE3APDE3BLMNACYP3A4 | |
| Papaverine SCHEMBL29356374 | 0.87 | PDE10A (1.00) | PDE10APDE3APDE3BLMNACYP3A4 | |
| Papaverine SCHEMBL8691148 | 0.87 | PDE10A (0.97) | PDE10APDE3APDE3BLMNACYP3A4 | |
| Papaverine SCHEMBL29696479 | 0.87 | PDE10A (1.00) | PDE10APDE3APDE3BLMNACYP3A4 | |
| Papaverine SCHEMBL677440 | 0.87 | PDE10A (0.97) | PDE10APDE3APDE3BLMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233761-B1 | OSMOTIC DOSAGE FORM COMPRISING FIRST AND SECOND COATS | ALZA CORP (US) | 2007-03-28 | — | — | EP | claimed |
| EP-1233761-A1 | OSMOTIC DOSAGE FORM COMPRISING FIRST AND SECOND COATS | ALZA Corporation (US) | 2002-08-28 | — | — | EP | claimed |
| WO-2001037815-A1 | OSMOTIC DOSAGE FORM COMPRISING FIRST AND SECOND | ALZA CORPORATION (US) | 2001-05-31 | — | — | WO | claimed |
| EP-1233761-B1 | OSMOTIC DOSAGE FORM COMPRISING FIRST AND SECOND COATS | ALZA CORP (US) | 2007-03-28 | — | — | EP | disclosed |
| EP-1233761-A1 | OSMOTIC DOSAGE FORM COMPRISING FIRST AND SECOND COATS | ALZA Corporation (US) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001037815-A1 | OSMOTIC DOSAGE FORM COMPRISING FIRST AND SECOND | ALZA CORPORATION (US) | 2001-05-31 | — | — | WO | disclosed |