Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 3/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.55 |
| ▸ | PLA2G2E | Q9NZK7 | 3/20 | 0.55 |
| ▸ | PLA2G2D | Q9UNK4 | 3/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.55 |
| ▸ | CCR2 | P41597 | 7/20 | 0.55 |
| ▸ | FDPS | P14324 | 2/20 | 0.47 |
| ▸ | PLA2G2F | Q9BZM2 | 2/20 | 0.46 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160158 | 0.92 | PLA2G10 (0.54) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL5160134 | 0.88 | KMT2A (0.55) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL6333151 | 0.79 | PLA2G2A (0.50) | PLA2G2ACCR2 | |
| SCHEMBL28310752 | 0.79 | KDM4E (0.60) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL14608289 | 0.78 | KMT2A (0.48) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL5158136 | 0.78 | KMT2A (0.48) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL14608171 | 0.74 | KMT2A (0.46) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL3275507 | 0.72 | CCR2 (0.62) | PLA2G1BPLA2G2ACCR2FDPSMEN1 | |
| SCHEMBL5160095 | 0.72 | PLA2G2A (0.52) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL5530394 | 0.71 | PLA2G2A (1.00) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358156-B1 | BENZ(G) INDOLES AND THEIR USE AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1358156-B1 | BENZ(G) INDOLES AND THEIR USE AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2007-02-21 | — | — | EP | disclosed |
| US-6916840-B2 | Spla2 inhibitors | ELI LILLY AND COMPANY (US) | 2005-07-12 | — | — | US | disclosed |
| US-20040063967-A1 | Novel spla2 inhibitors | BEIGHT DOUGLAS WADE (US) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063967-A1 | Novel spla2 inhibitors | PLA2G12A, SPINT2, PLA2G4A | PLA2G10 18/4885PLA2G1B 14/4885PLA2G2E 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.