Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.45 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.43 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.43 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.43 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.43 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.43 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.43 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.43 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.43 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122648 | 0.85 | ALDH1A1 (0.47) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL6831591 | 0.84 | NPC1 (0.45) | MEN1KMT2AMAPTNPC1PPARG | |
| SCHEMBL6832690 | 0.83 | GAA (0.48) | MEN1KMT2APPARGPPARAMMP2 | |
| SCHEMBL6827929 | 0.83 | GAA (0.48) | MEN1KMT2APPARGPPARAMMP2 | |
| SCHEMBL6830781 | 0.82 | MEN1 (0.48) | MEN1KMT2AMAPTNPC1PPARG | |
| SCHEMBL8665299 | 0.82 | CTSS (0.49) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7367395 | 0.81 | NPC1 (0.47) | MEN1KMT2ANPC1PPARGPPARA | |
| SCHEMBL5523207 | 0.81 | CTSS (0.50) | CTSSCTSK | |
| SCHEMBL5163314 | 0.79 | CTSS (0.60) | BCL2PPARGPPARACTSSCTSK | |
| SCHEMBL6409791 | 0.79 | CTSS (0.60) | BCL2PPARGPPARACTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753733-A1 | SMALL MOLECULES FOR TREATMENT OF HYPERCHOLESTEROLEMIA AND RELATED DISEASES | Avanir Pharmaceuticals (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005123700-A1 | SMALL MOLECULES FOR TREATMENT OF HYPERCHOLESTEROLEMIA AND RELATED DISEASES | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |