Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165966 | 0.76 | MAPT (0.78) | KMT2ALMNAMAPTKDM4EGAA | |
| SCHEMBL5162085 | 0.74 | KMT2A (0.64) | KMT2ALMNAMAPTKDM4EGAA | |
| SCHEMBL23657600 | 0.73 | LMNA (1.00) | KMT2ALMNAMAPTKDM4EGAA | |
| SCHEMBL10679636 | 0.72 | PRMT5 (0.62) | LMNAALDH1A1TSHRARSMN1; SMN2 | |
| SCHEMBL5160240 | 0.71 | MAPT (1.00) | KMT2ALMNAMAPTKDM4EGAA | |
| SCHEMBL5160111 | 0.71 | MAPT (0.75) | KMT2ALMNAMAPTKDM4EGAA | |
| SCHEMBL3475619 | 0.70 | KDM4E (1.00) | KMT2ALMNAKDM4EGAAHTT | |
| SCHEMBL13858810 | 0.69 | KDM4E (0.66) | KMT2ALMNAMAPTKDM4EGAA | |
| SCHEMBL30989583 | 0.69 | ATM (0.56) | KMT2ALMNAMAPTKDM4EGAA | |
| SCHEMBL5161752 | 0.68 | MAPT (1.00) | KMT2ALMNAMAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1231982-B1 | USE OF PHTHALAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | ABBOTT GMBH & CO KG (DE) | 2007-03-21 | — | — | EP | disclosed |
| US-6903098-B1 | Use of phthalazine derivatives | ABBOTT GMBH & CO. (DE) | 2005-06-07 | — | — | US | disclosed |