Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.52 |
| ▸ | MMP9 | P14780 | 9/20 | 0.52 |
| ▸ | MMP2 | P08253 | 4/20 | 0.52 |
| ▸ | MMP12 | P39900 | 3/20 | 0.52 |
| ▸ | MMP14 | P50281 | 3/20 | 0.52 |
| ▸ | MMP15 | P51511 | 3/20 | 0.52 |
| ▸ | MMP16 | P51512 | 3/20 | 0.52 |
| ▸ | MMP26 | Q9NRE1 | 3/20 | 0.52 |
| ▸ | MMP7 | P09237 | 5/20 | 0.51 |
| ▸ | MMP3 | P08254 | 6/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 5/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160366 | 0.92 | MMP1 (0.51) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL5159963 | 0.90 | THRB (0.49) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL5160245 | 0.90 | THRB (0.49) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL5163691 | 0.89 | MMP1 (0.55) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL5165012 | 0.89 | MMP1 (0.48) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL4692409 | 0.89 | TAS2R14 (0.54) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL5164250 | 0.89 | MMP1 (0.69) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL5435855 | 0.88 | TAS2R14 (0.51) | MMP1MMP9MMP2MMP12MMP14 | |
| SCHEMBL5162513 | 0.87 | MMP1 (0.47) | MMP1MMP9MMP2MMP14MMP7 | |
| SCHEMBL5163119 | 0.87 | MMP1 (0.47) | MMP1MMP9MMP2MMP14MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763516-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002763-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |