SCHEMBL5164301

SCHEMBL5164301

O=[N+]([O-])c1ccc(OP(O)(=S)Cl)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.66
CA2 P00918 3/20 0.66
CES2 O00748 1/20 0.66
CES1 P23141 1/20 0.66
ALDH1A1 P00352 4/20 0.60
MAPK1 P28482 3/20 0.60
CYP3A4 P08684 2/20 0.60
HSD17B10 Q99714 2/20 0.60
LMNA P02545 1/20 0.60
TP53 P04637 1/20 0.60
THRB P10828 1/20 0.60
SMN1; SMN2 Q16637 1/20 0.60
TSHR P16473 1/20 0.55
BCHE P06276 1/20 0.49
ACHE P22303 1/20 0.49
GAA P10253 1/20 0.47
KMT2A Q03164 3/20 0.45
MEN1 O00255 2/20 0.45
BCL9 O00512 1/20 0.45
CTNNB1 P35222 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1097455 0.85 ALDH1A1 (0.64) CA1CA2CES2CES1ALDH1A1
SCHEMBL8877085 0.85 ALDH1A1 (0.64) CA1CA2CES2CES1ALDH1A1
SCHEMBL955844 0.85 CA1 (0.70) CA1CA2CES2CES1ALDH1A1
SCHEMBL972719 0.84 CA1 (0.73) CA1CA2CES2CES1ALDH1A1
SCHEMBL28841894 0.82 CA1 (0.66) CA1CA2CES2CES1ALDH1A1
SCHEMBL8837359 0.81 ALDH1A1 (0.79) CA1CA2CES2CES1ALDH1A1
SCHEMBL6049724 0.80 CA1 (0.62) CA1CA2CES2CES1ALDH1A1
SCHEMBL972717 0.79 CA1 (0.67) CA1CA2CES2CES1ALDH1A1
SCHEMBL851431 0.79 CA1 (0.67) CA1CA2CES2CES1ALDH1A1
SCHEMBL223704 0.79 CES1 (1.00) CA1CA2CES2CES1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1765844-A2 PURINE NUCLEOTIDE DERIVATIVES Lauras AS (NO) 2007-03-28 EP disclosed
US-7098341-B2 Process for preparing haptens for immunoassay of phosphorothioate pesticides Lee, Yong-Tae (KR) 2006-08-29 US disclosed
WO-2005123755-A2 PURINE NUCLEOTIDE DERIVATIVES LAURAS AS (NO) 2005-12-29 WO disclosed
US-20050033038-A1 Process for preparing haptens for immunoassay of phosphorothioate pesticides KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2005-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050033038-A1 Process for preparing haptens for immunoassay of phosphorothioate pesticides PTMS, DDT, DNPEP CA1 944/4885CA2 557/4885CES2 629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.