Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.67 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239140 | 0.97 | APOBEC3A (0.70) | APOBEC3AAPOBEC3GKDM4EALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL237898 | 0.87 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GKDM4EALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL28458738 | 0.87 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GKDM4EALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL30862487 | 0.84 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GKDM4EALDH1A1TDP1 | |
| Bromide SCHEMBL30600378 | 0.84 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GKDM4EALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL2584896 | 0.84 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GKDM4EALDH1A1TDP1 | |
| Water SCHEMBL27434927 | 0.84 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GKDM4EALDH1A1TDP1 | |
| SCHEMBL2385111 | 0.84 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GKDM4EALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL2584894 | 0.84 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GKDM4EALDH1A1TDP1 | |
| SCHEMBL147815 | 0.84 | APOBEC3A (0.93) | APOBEC3AAPOBEC3GKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560833-B1 | PREPARATION OF CODEINE FROM MORPHINE | MALLINCKRODT INTERNAT CORP (US) | 2007-03-14 | — | — | EP | claimed |