Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CCNH | P51946 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2984988 | 0.88 | KDR (0.36) | CDK1KDREEDPDCD1CD274 | |
| SCHEMBL5149053 | 0.84 | ALDH1A1 (0.41) | HTTALDH1A1NPC1LMNAGAA | |
| Tert-Butyl Formate SCHEMBL27688664 | 0.83 | CDK1 (0.33) | CDK1KDRCCNCCDK8 | |
| SCHEMBL28770296 | 0.82 | KDR (0.37) | CDK1KDREEDHAVCR2CDK7 | |
| SCHEMBL5147429 | 0.81 | ADORA1 (0.37) | HTTALDH1A1NPC1LMNAGAA | |
| SCHEMBL5147378 | 0.81 | ADORA1 (0.40) | HTTALDH1A1NPC1LMNAGAA | |
| SCHEMBL5146079 | 0.80 | ALDH1A1 (0.38) | HTTALDH1A1NPC1LMNAGAA | |
| SCHEMBL5145833 | 0.78 | ALDH1A1 (0.43) | HTTALDH1A1NPC1LMNAGAA | |
| SCHEMBL5147468 | 0.76 | SMN1; SMN2 (0.40) | HTTALDH1A1NPC1LMNAGAA | |
| SCHEMBL2986424 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |