Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149053 | 0.92 | ALDH1A1 (0.41) | ALDH1A1ADORA1LMNAHTTTSHR | |
| SCHEMBL5147378 | 0.85 | ADORA1 (0.40) | ALDH1A1ADORA1LMNAHTTTSHR | |
| SCHEMBL2980841 | 0.84 | ADORA1 (0.40) | ALDH1A1ADORA1LMNATSHRMAPK1 | |
| SCHEMBL5147429 | 0.84 | ADORA1 (0.37) | ALDH1A1ADORA1LMNAHTTTSHR | |
| SCHEMBL5147485 | 0.82 | RAF1 (0.39) | ALDH1A1ADORA1LMNAHTTTSHR | |
| SCHEMBL5145850 | 0.82 | HSD17B1 (0.38) | ALDH1A1ADORA1LMNAHTTTSHR | |
| SCHEMBL5179687 | 0.81 | ADORA1 (0.37) | ALDH1A1ADORA1ADORA2A | |
| SCHEMBL5147347 | 0.80 | ADORA1 (0.38) | ALDH1A1ADORA1HTTSMN1; SMN2ABL1 | |
| SCHEMBL5147476 | 0.80 | HSD17B1 (0.39) | ALDH1A1ADORA1LMNAHTTTSHR | |
| SCHEMBL5149006 | 0.79 | ADORA1 (0.39) | ALDH1A1ADORA1HTTSMN1; SMN2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |