SCHEMBL5168960

SCHEMBL5168960

O=C(Nc1ccc(-c2ccc(CO)cc2)cc1)[C@H]1CN2CCC1CC2

nearest known ligand 0.66

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.43
RAB9A P51151 2/20 0.43
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
PTPN1 P18031 3/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 1/20 0.42
HPGD P15428 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
GAA P10253 1/20 0.41
TSHR P16473 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10006859 1.00 LMNA (0.43) LMNARAB9AMEN1KMT2APTPN1
SCHEMBL1460442 1.00 LMNA (0.43) LMNARAB9AMEN1KMT2APTPN1
Hydrochloric Acid SCHEMBL5168574 0.99 LMNA (0.42) LMNARAB9AMEN1KMT2APTPN1
Hydrochloric Acid SCHEMBL5167317 0.99 LMNA (0.42) LMNARAB9AMEN1KMT2APTPN1
Hydrochloric Acid SCHEMBL5166751 0.99 LMNA (0.42) LMNARAB9AMEN1KMT2APTPN1
SCHEMBL9967270 0.85 RAB9A (0.59) LMNARAB9AMEN1KMT2APTPN1
SCHEMBL9967272 0.84 RAB9A (0.45) LMNARAB9AMEN1KMT2APTPN1
SCHEMBL1459729 0.84 PTPN1 (0.54) LMNARAB9AMEN1KMT2APTPN1
SCHEMBL1458620 0.84 TP53 (0.41) KMT2ASMN1; SMN2
SCHEMBL1459332 0.84 FPR1 (0.46) LMNARAB9AMEN1KMT2APTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2025-02-04 US disclosed
US-20220316011-A1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2022-10-06 US disclosed
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2022-06-14 US disclosed
US-20210338621-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2021-11-04 US disclosed
US-20200108035-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2020-04-09 US disclosed
US-20180037957-A1 BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2018-02-08 US disclosed
EP-2931315-B1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2017-11-29 EP disclosed
US-9828642-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2017-11-28 US disclosed
US-20150275303-A1 BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2015-10-01 US disclosed
US-20140228398-A1 COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE NOVARTIS AG (CH) 2014-08-14 US disclosed
US-20140171448-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG (CH) 2014-06-19 US disclosed
US-20120172346-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS NOVARTIS AG 2012-07-05 US disclosed
EP-1487834-B1 AZA-BICYCLIC N-BIARYLAMIDES WITH AFFINITY FOR THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR BAYER HEALTHCARE AG (DE) 2007-04-25 EP disclosed
US-7138410-B2 Aza-bicyclic N-biarylamides with affinity for the α7 nicotinic acetylcholine receptor BAYER HEALTHCARE AG (DE) 2006-11-21 US disclosed
US-20050154045-A1 Aza-bicyclic n-biarylamides with affinity for the alpha-7 nicotinic acetylcholine receptor BAYER HEALTHCARE AG (DE) 2005-07-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150275303-A1 BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT CHRNA7, CHRNA4, CHRNA5 LMNA 3629/4885RAB9A 1278/4885MEN1 4568/4885
US-20180037957-A1 BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT CHRNA7, CHRNA4, CHRNA5 LMNA 3629/4885RAB9A 1278/4885MEN1 4568/4885
US-20140171448-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNG, CHRNA6 LMNA 2881/4885RAB9A 732/4885MEN1 4124/4885
US-20140228398-A1 COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE CHRNA5, GRM5, CHRNA7 LMNA 4782/4885RAB9A 477/4885MEN1 4840/4885
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 LMNA 3722/4885RAB9A 1259/4885MEN1 4563/4885
US-20120172346-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 LMNA 3873/4885RAB9A 494/4885MEN1 4830/4885
US-20050154045-A1 Aza-bicyclic n-biarylamides with affinity for the alpha-7 nicotinic acetylcholine receptor CHRNA7, CHRNA5, CHRNA2 LMNA 2887/4885RAB9A 2177/4885MEN1 3795/4885
US-20220316011-A1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT CHRNA7, CHRNA4, CHRNA5 LMNA 3722/4885RAB9A 1259/4885MEN1 4563/4885
US-20200108035-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 LMNA 3873/4885RAB9A 494/4885MEN1 4830/4885
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 LMNA 3629/4885RAB9A 1278/4885MEN1 4568/4885
US-20210338621-A1 USE OF NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA 7 ACTIVATORS CHRNA7, CHRNA5, CHRNA4 LMNA 3873/4885RAB9A 494/4885MEN1 4830/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.