Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.62 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.54 |
| ▸ | ITGAM | P11215 | 2/20 | 0.54 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.54 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5169570 | 1.00 | MAP3K5 (0.62) | MAP3K5DUSP3MEN1KMT2ASTAT3 | |
| SCHEMBL5167082 | 0.85 | ITGB2 (0.77) | MAP3K5MEN1KMT2AITGB2ITGAM | |
| SCHEMBL5167090 | 0.85 | ITGB2 (0.77) | MAP3K5MEN1KMT2AITGB2ITGAM | |
| SCHEMBL5143138 | 0.85 | PTPN22 (0.66) | MAP3K5MEN1KMT2AITGB2ITGAM | |
| SCHEMBL5143140 | 0.85 | PTPN22 (0.66) | MAP3K5MEN1KMT2AITGB2ITGAM | |
| SCHEMBL17088410 | 0.84 | ITGB2 (0.71) | MEN1KMT2ASTAT3ITGB2ITGAM | |
| SCHEMBL5160926 | 0.82 | MEN1 (0.67) | MEN1KMT2AITGB2ITGAMMAPT | |
| SCHEMBL5160915 | 0.82 | MEN1 (0.67) | MEN1KMT2AITGB2ITGAMMAPT | |
| SCHEMBL5146767 | 0.81 | STAT3 (0.80) | MEN1KMT2ASTAT3ITGB2ITGAM | |
| SCHEMBL5146772 | 0.81 | STAT3 (0.80) | MEN1KMT2ASTAT3ITGB2ITGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718308-A4 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORP (CA) | 2007-07-18 | — | — | EP | disclosed |
| EP-1718308-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PainCeptor Pharma Corp. (CA) | 2006-11-08 | — | — | EP | disclosed |
| US-20050282840-A1 | Methods of modulating neurotrophin-mediated activity | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-12-22 | — | — | US | disclosed |
| WO-2005076695-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282840-A1 | Methods of modulating neurotrophin-mediated activity | NGF, BDNF, NTRK2 | MAP3K5 2933/4885DUSP3 1894/4885MEN1 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.