Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | GHSR | Q92847 | 2/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171940 | 0.91 | CYP4F2 (0.35) | HRH3HRH1BACE1CYP4F2CYP4A11 | |
| SCHEMBL5172012 | 0.88 | HRH3 (0.40) | HRH3HRH1CYP4F2CYP4A11GRIN2B | |
| SCHEMBL5194058 | 0.88 | HRH3 (0.41) | HRH3GRM5 | |
| SCHEMBL5171051 | 0.87 | HRH3 (0.35) | HRH3HRH1PARP1PARP2 | |
| SCHEMBL5171939 | 0.85 | HRH3 (0.40) | HRH3HRH1BACE1GRIN2BGRIN1 | |
| SCHEMBL5170953 | 0.82 | CHRNB2 (0.39) | CYP4F2CYP4A11GRIN2BGRIN1GRM5 | |
| SCHEMBL5170240 | 0.80 | HRH3 (0.35) | HRH3CSF1RPARP1HDAC3HDAC1 | |
| SCHEMBL5172261 | 0.79 | KLKB1 (0.38) | — | |
| SCHEMBL5170762 | 0.79 | SMO (0.33) | CYP4F2CYP4A11GHSRPARP1 | |
| SCHEMBL5169161 | 0.78 | PRMT5 (0.36) | HRH3GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |